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    Gbp8 guanylate-binding protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 76074, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gbp8provided by MGI
    Official Full Name
    guanylate-binding protein 8provided by MGI
    Primary source
    MGI:MGI:1923324
    See related
    Ensembl:ENSMUSG00000034438 AllianceGenome:MGI:1923324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGBP8; 5830443L24Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cellular response to interferon-gamma. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 14.5), spleen adult (RPKM 2.9) and 7 other tissues See more
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    Genomic context

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    See Gbp8 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105160379..105201475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105012513..105053609, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24097 Neighboring gene ATP binding cassette subfamily G member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:105411589-105411825 Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_13847 Neighboring gene guanylate-binding protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E1304 Neighboring gene guanylate binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
    2. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson DS, et al. Immunity, 2022 Mar 8. PMID 35139355, Free PMC Article
    3. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate binding protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029509.4 → NP_083785.3  guanylate binding protein 8

      See identical proteins and their annotated locations for NP_083785.3

      Status: VALIDATED

      Source sequence(s)
      AC144914, BY089370, DQ295175
      Consensus CDS
      CCDS19490.1
      UniProtKB/TrEMBL
      F7CE50, Q2V6D6
      Related
      ENSMUSP00000031235.7, ENSMUST00000031235.13
      Conserved Domains (2) summary
      pfam02841
      Location:206 → 493
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:16 → 207
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105160379..105201475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535283.2 → XP_006535346.1  guanylate binding protein 8 isoform X4

      Conserved Domains (2) summary
      pfam02841
      Location:63 → 348
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:16 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_011249593.1 → XP_011247895.1  guanylate binding protein 8 isoform X5

      Conserved Domains (2) summary
      pfam02263
      Location:16 → 280
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:282 → 576
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_017321140.2 → XP_017176629.1  guanylate binding protein 8 isoform X2

      Conserved Domains (2) summary
      pfam02841
      Location:129 → 416
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_017321142.3 → XP_017176631.1  guanylate binding protein 8 isoform X3

      UniProtKB/TrEMBL
      Q66K09
      Conserved Domains (2) summary
      pfam02841
      Location:78 → 365
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 79
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_017321141.3 → XP_017176630.1  guanylate binding protein 8 isoform X3

      UniProtKB/TrEMBL
      Q66K09
      Conserved Domains (2) summary
      pfam02841
      Location:78 → 365
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:1 → 79
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_006535281.5 → XP_006535344.1  guanylate binding protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006535344.1

      UniProtKB/TrEMBL
      F7CE50, Q2V6D6
      Conserved Domains (2) summary
      pfam02841
      Location:206 → 493
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl38936
      Location:16 → 207
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_389295.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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