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    Alg11 ALG11 alpha-1,2-mannosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 207958, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Alg11provided by MGI
    Official Full Name
    ALG11 alpha-1,2-mannosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2142632
    See related
    Ensembl:ENSMUSG00000063362 AllianceGenome:MGI:2142632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mmat-4(5); B230397C21
    Summary
    Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.0), bladder adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg11 in Genome Data Viewer
    Location:
    8 A2; 8 10.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22550731..22561643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22060721..22071627)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 70 Neighboring gene STARR-seq mESC enhancer starr_20896 Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E2858 Neighboring gene STARR-seq mESC enhancer starr_20897 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene STARR-seq mESC enhancer starr_20898 Neighboring gene predicted gene, 57529 Neighboring gene STARR-seq mESC enhancer starr_20899 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene STARR-seq mESC enhancer starr_20900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides. Nishimura Y, et al. Biosci Biotechnol Biochem, 2014. PMID 25036826
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hence, we concluded that there is different transcriptional control mechanism between mALG11 and hALG11
      Title: Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    Names
    asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
    asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
    asparagine-linked glycosylation protein 11 homolog
    defective mannosyltransferase IV(V)
    glycolipid 2-alpha-mannosyltransferase
    mannosyltransferase IV(V)
    NP_001230090.1
    NP_898965.1
    XP_006509108.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243161.1 → NP_001230090.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001230090.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK157746, BC061469
      Consensus CDS
      CCDS57613.1
      UniProtKB/Swiss-Prot
      Q3TZM9, Q6P7W8, Q8BL38
      UniProtKB/TrEMBL
      A0A077K846
      Related
      ENSMUSP00000072382.7, ENSMUST00000072572.13
      Conserved Domains (2) summary
      cd03806
      Location:64 → 480
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:64 → 492
      PLN02949; transferase, transferring glycosyl groups

    2. NM_183142.4 → NP_898965.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_898965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK046475, AK157746, BC061469
      Consensus CDS
      CCDS40292.1
      UniProtKB/Swiss-Prot
      Q3TZM9
      Related
      ENSMUSP00000106365.3, ENSMUST00000110737.3
      Conserved Domains (2) summary
      cd03806
      Location:64 → 438
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:64 → 450
      PLN02949; transferase, transferring glycosyl groups

    RNA

    1. NR_040650.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site that introduces a premature stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK157746, BC061469

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22550731..22561643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509045.3 → XP_006509108.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

      Conserved Domains (1) summary
      cd03806
      Location:39 → 455
      GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TZM9.1 GenPept UniProtKB/Swiss-Prot:Q3TZM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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