TNIP2 TNFAIP3 interacting protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNIP2provided by HGNC
Official Full Name: TNFAIP3 interacting protein 2provided by HGNC
Primary source: HGNC:HGNC:19118
See related: Ensembl:ENSG00000168884 MIM:610669; AllianceGenome:HGNC:19118
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KLIP; ABIN2; FLIP1
Summary: This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
Expression: Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (2741648..2756336, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (2740398..2755095, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (2743375..2758063, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation.
Title: TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation.
TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study.
Title: TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study.
Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis.
Title: Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis.
TNIP2 mediates GRbeta-promoted inflammation and is associated with severity of major depressive disorder.
Title: TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder.
The increased inflammation of Map3k8(-/-) mice in allergic airway inflammation and colitis results from reduced ABIN-2 signaling, rather than blocked TPL-2 signaling.
Title: ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation.
the data indicated that TNIP2 is significantly decreased in MODS following severe trauma, and it plays a protective role in MODS development by inhibiting the inflammation response and oxidative stress by preventing NFkappaB activation.
Title: Expression and role of TNIP2 in multiple organ dysfunction syndrome following severe trauma.
RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein.
Title: Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection.
Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20.
Title: Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-κB, ABIN-2.
Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs.
Title: TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.
miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma.
Title: MiR-1180 promoted the proliferation of hepatocellular carcinoma cells by repressing TNIP2 expression.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-68050 (e-PCR)
- UniSTS:5182

SHGC-67741 (e-PCR)
- UniSTS:39233

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CD40 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 2 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor 3 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 3 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor 9 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: TNFAIP3-interacting protein 2

Names: A20-binding inhibitor of NF-kappaB activation-2; fetal liver LKB1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161527.2 → NP_001154999.1 TNFAIP3-interacting protein 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK026176, AL110117, AL121750, BC002740, DA421921

Consensus CDS

CCDS54714.1

UniProtKB/Swiss-Prot

Q8NFZ5

Related

ENSP00000427613.1, ENST00000510267.5

Conserved Domains (2) summary

pfam12180
Location:107 → 139

EABR; TSG101 and ALIX binding domain of CEP55

cl15254
Location:151 → 232

UBAN; polyubiquitin binding domain of NEMO and related proteins
NM_001292016.2 → NP_001278945.1 TNFAIP3-interacting protein 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter than isoform 1.

Source sequence(s)

AF372839, AL110117, BC002740, BX386180, CB157550

Consensus CDS

CCDS75093.1

UniProtKB/TrEMBL

D6RGJ2

Related

ENSP00000426314.1, ENST00000503235.1

Conserved Domains (1) summary

COG1196
Location:20 → 251

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_024309.4 → NP_077285.3 TNFAIP3-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_077285.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF372839, AL110117, BC002740

Consensus CDS

CCDS3362.1

UniProtKB/Swiss-Prot

B1AKS4, B3KTY8, D3DVQ9, Q7L5L2, Q8NFZ5, Q9BQR6, Q9H682

Related

ENSP00000321203.7, ENST00000315423.12

Conserved Domains (2) summary

pfam12180
Location:214 → 246

EABR; TSG101 and ALIX binding domain of CEP55

cl15254
Location:258 → 339

UBAN; polyubiquitin binding domain of NEMO and related proteins