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    Cxxc5 CXXC finger 5 [ Mus musculus (house mouse) ]

    Gene ID: 67393, updated on 8-May-2024

    Summary

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    Official Symbol
    Cxxc5provided by MGI
    Official Full Name
    CXXC finger 5provided by MGI
    Primary source
    MGI:MGI:1914643
    See related
    Ensembl:ENSMUSG00000046668 AllianceGenome:MGI:1914643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930415K17Rik
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; methyl-CpG binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 24.2), testis adult (RPKM 22.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cxxc5 in Genome Data Viewer
    Location:
    18 B2; 18 19.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35962432..35994746)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35829379..35861693)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44252 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2D 2A Neighboring gene STARR-seq mESC enhancer starr_44255 Neighboring gene STARR-seq mESC enhancer starr_44256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35991804-35992030 Neighboring gene predicted gene 29417 Neighboring gene VISTA enhancer mm1664 Neighboring gene STARR-positive B cell enhancer mm9_chr18:36003985-36004286 Neighboring gene VISTA enhancer mm1614 Neighboring gene STARR-positive B cell enhancer ABC_E1206 Neighboring gene predicted gene, 41693 Neighboring gene STARR-seq mESC enhancer starr_44261 Neighboring gene predicted gene, 36315

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment. Seo SH, et al. Exp Mol Med, 2022 Sep. PMID 36114279, Free PMC Article
    2. CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway. Cheng W, et al. Biomed Res Int, 2020. PMID 32337277, Free PMC Article
    3. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. Ma S, et al. J Exp Med, 2017 May 1. PMID 28416650, Free PMC Article
    4. CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Kim MY, et al. Glia, 2016 Mar. PMID 26462610
    5. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Kim HY, et al. Cell Death Differ, 2015 Jun. PMID 25633194, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
      Title: CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis.
    2. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
      Title: Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
    3. Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway.
      Title: Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway.
    4. Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
      Title: Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
    5. Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
      Title: Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
    6. CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
      Title: CXXC5 orchestrates Stat3/Erk/Akt signaling networks to modulate P. gingivalis-elicited autophagy in cementoblasts.
    7. CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
      Title: CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway.
    8. Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
      Title: Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
    9. These results reveal an important role for CXXC5 as a suppressor of longitudinal bone growth involving growth plate activity.
      Title: CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.
    10. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
      Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101987

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CXXC-type zinc finger protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357458.1 → NP_001344387.1  CXXC-type zinc finger protein 5

      Status: VALIDATED

      Source sequence(s)
      AC141471, AI843749
      Consensus CDS
      CCDS29150.1
      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    2. NM_001357459.1 → NP_001344388.1  CXXC-type zinc finger protein 5

      Status: VALIDATED

      Source sequence(s)
      AC141471, AI843749, AK132950, BC089314
      Consensus CDS
      CCDS29150.1
      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    3. NM_133687.3 → NP_598448.1  CXXC-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_598448.1

      Status: VALIDATED

      Source sequence(s)
      AI843749, BC089314, BY705532
      Consensus CDS
      CCDS29150.1
      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Related
      ENSMUSP00000054307.7, ENSMUST00000060722.8
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35962432..35994746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526180.3 → XP_006526243.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006526243.1

      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    2. XM_006526176.5 → XP_006526239.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006526239.1

      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    3. XM_030250576.2 → XP_030106436.1  CXXC-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    4. XM_036161256.1 → XP_036017149.1  CXXC-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain

    5. XM_006526181.5 → XP_006526244.1  CXXC-type zinc finger protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006526244.1

      UniProtKB/Swiss-Prot
      Q3V0R4, Q8CES6, Q8CF49, Q91WA4
      Conserved Domains (1) summary
      pfam02008
      Location:250 → 291
      zf-CXXC; CXXC zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WA4.1 GenPept UniProtKB/Swiss-Prot:Q91WA4

    Gene LinkOut

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