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    Uhmk1 U2AF homology motif (UHM) kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 16589, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Uhmk1provided by MGI
    Official Full Name
    U2AF homology motif (UHM) kinase 1provided by MGI
    Primary source
    MGI:MGI:1341908
    See related
    Ensembl:ENSMUSG00000026667 AllianceGenome:MGI:1341908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KIS; Kist; P-CIP2; 4732477C12Rik; 4930500M09Rik; C820018A03Rik
    Summary
    Enables ribonucleoprotein complex binding activity. Involved in neuron projection development and positive regulation of translational initiation. Located in axon; dendrite cytoplasm; and neuronal ribonucleoprotein granule. Is expressed in brain; heart; liver; metanephros; and musculature. Orthologous to human UHMK1 (U2AF homology motif kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.7), ovary adult (RPKM 8.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H3; 1 76.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170020989..170043466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170193422..170215897, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene discoidin domain receptor family, member 2 Neighboring gene STARR-seq mESC enhancer starr_02981 Neighboring gene STARR-seq mESC enhancer starr_02982 Neighboring gene STARR-seq mESC enhancer starr_02983 Neighboring gene STARR-seq mESC enhancer starr_02984 Neighboring gene STARR-seq mESC enhancer starr_02986 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4380 Neighboring gene STARR-seq mESC enhancer starr_02987 Neighboring gene STARR-positive B cell enhancer ABC_E3325 Neighboring gene STARR-seq mESC enhancer starr_02988 Neighboring gene STARR-seq mESC enhancer starr_02989 Neighboring gene STARR-positive B cell enhancer mm9_chr1:172185797-172186097 Neighboring gene SH2 domain containing 1B2 Neighboring gene predicted gene 6345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling. Pedraza N, et al. J Neurosci, 2014 Oct 15. PMID 25319695, Free PMC Article
    2. UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. Feng X, et al. EMBO J, 2020 Mar 2. PMID 31975428, Free PMC Article
    3. Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. Manceau V, et al. J Mol Biol, 2008 Sep 5. PMID 18588901, Free PMC Article
    4. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Bièche I, et al. Brain Res Mol Brain Res, 2003 May 26. PMID 12782393
    5. KIS is a protein kinase with an RNA recognition motif. Maucuer A, et al. J Biol Chem, 1997 Sep 12. PMID 9287318

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
      Title: UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
    2. The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines.
      Title: KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
    3. disregulation of gene expression due to KIS inactivation affects specific brain functions.
      Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
    4. Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.
      Title: Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.
    5. KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.
      Title: Protein kinase KIS localizes to RNA granules and enhances local translation.
    6. Phosphorylation of p27Kip1 by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin phosphorylation in VSMCs
      Title: KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.
    7. Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.
      Title: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables splicing factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Kist
    Names
    PAM COOH-terminal interactor protein 2
    U2AF homology motif kinase 1
    kinase interacting with leukemia-associated gene (stathmin)
    kinase interacting with stathmin
    NP_001347738.1
    NP_034763.3
    XP_006496745.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360809.1 → NP_001347738.1  serine/threonine-protein kinase Kist isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC123650, AK030152
      Consensus CDS
      CCDS87917.1
      UniProtKB/TrEMBL
      Q8C0N6
      Related
      ENSMUSP00000115622.2, ENSMUST00000150821.8
      Conserved Domains (2) summary
      cd12465
      Location:229 → 316
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      cl21453
      Location:1 → 219
      PKc_like; Protein Kinases, catalytic domain

    2. NM_010633.4 → NP_034763.3  serine/threonine-protein kinase Kist isoform 1

      See identical proteins and their annotated locations for NP_034763.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123650, BC058732
      Consensus CDS
      CCDS15468.1
      UniProtKB/Swiss-Prot
      P97343, Q61775, Q9CYT1
      Related
      ENSMUSP00000027979.8, ENSMUST00000027979.14
      Conserved Domains (2) summary
      cd12465
      Location:318 → 405
      RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
      cd14020
      Location:22 → 308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170020989..170043466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496682.4 → XP_006496745.1  serine/threonine-protein kinase Kist isoform X1

      UniProtKB/TrEMBL
      D3YUF5
      Related
      ENSMUSP00000120787.2, ENSMUST00000123399.2
      Conserved Domains (2) summary
      cd14020
      Location:22 → 308
      STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
      cl17169
      Location:318 → 341
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_004940648.1 RNA Sequence

    2. XR_004940646.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97343.3 GenPept UniProtKB/Swiss-Prot:P97343

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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