CD8B CD8 subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD8Bprovided by HGNC
Official Full Name: CD8 subunit betaprovided by HGNC
Primary source: HGNC:HGNC:1707
See related: Ensembl:ENSG00000172116 MIM:186730; AllianceGenome:HGNC:1707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta
Summary: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
Expression: Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p11.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (86815369..86861886, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (86817280..86863804, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (87042492..87089009, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
Title: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
CD45RA, CD8beta, and IFNgamma Are Potential Immune Biomarkers of Human Cognitive Function.
Title: CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.
results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored
Title: Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2.
Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.
Title: CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas.
CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
Title: cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.
Title: cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.
Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.
Title: Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
[review] Coreceptor CD8alphabeta contributes to the antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling.
Title: The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma.
Title: Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env	PubMed
Nef	nef	HIV-1 Nef downregulates surface expression of the beta-chain of the CD8 receptor by accelerated endocytosis; amino acid positions 57 to 58 and 174 to 175 in Nef are involved in the down modulation	PubMed
	nef	HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation	PubMed
	nef	Downregulation of CD8beta by HIV-1 Nef requires an intact AP-2 complex	PubMed
	nef	Co-localization of HIV-1 Nef and CD8beta is revealed by staining assays in 293T cells expressing both proteins	PubMed
Pol	gag-pol	HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70958 (e-PCR)
- UniSTS:2826

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

NoName (e-PCR)
- UniSTS:482959

SHGC-11929 (e-PCR)
- UniSTS:54999

D2S2568 (e-PCR)
- UniSTS:44014

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MHC class I protein binding	NAS Non-traceable Author Statement more info	PubMed
enables coreceptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of T cell receptor complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD8 beta chain

Names: CD8 antigen, beta polypeptide 1 (p37); CD8b molecule; Ly-3 homolog; T lymphocyte surface glycoprotein beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001178100.2 → NP_001171571.1 T-cell surface glycoprotein CD8 beta chain isoform 6 precursor

See identical proteins and their annotated locations for NP_001171571.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2.

Source sequence(s)

AW296309, BC100912, DC405359, X13445

Consensus CDS

CCDS54376.1

UniProtKB/TrEMBL

Q9UQ56

Related

ENSP00000377358.2, ENST00000393761.6

Conserved Domains (2) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

smart00410
Location:26 → 134

IG_like; Immunoglobulin like
NM_004931.5 → NP_004922.1 T-cell surface glycoprotein CD8 beta chain isoform 5 precursor

See identical proteins and their annotated locations for NP_004922.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2.

Source sequence(s)

AC111200, BC100912, BP392114, DB223179, DC405359, X13444

Consensus CDS

CCDS1997.1

UniProtKB/Swiss-Prot

P10966, P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2, Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8, Q9UDB9, Q9UDC0, Q9UQ55

UniProtKB/TrEMBL

E9PD41

Related

ENSP00000375070.6, ENST00000390655.12

Conserved Domains (2) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

smart00410
Location:26 → 134

IG_like; Immunoglobulin like
NM_172101.5 → NP_742099.1 T-cell surface glycoprotein CD8 beta chain isoform 3 precursor

See identical proteins and their annotated locations for NP_742099.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AW296309, BC100912, DC405359, X13445

Consensus CDS

CCDS42708.1

UniProtKB/TrEMBL

B4E0F8, E7EPH5

Related

ENSP00000377356.2, ENST00000393759.6

Conserved Domains (2) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

smart00410
Location:26 → 134

IG_like; Immunoglobulin like
NM_172102.5 → NP_742100.1 T-cell surface glycoprotein CD8 beta chain isoform 4 precursor

See identical proteins and their annotated locations for NP_742100.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2.

Source sequence(s)

AW296309, BC100912, DC405359, X13446

Consensus CDS

CCDS1994.1

UniProtKB/TrEMBL

B4E0F8, E7EPH5

Related

ENSP00000340592.3, ENST00000349455.7

Conserved Domains (2) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

smart00410
Location:26 → 134

IG_like; Immunoglobulin like
NM_172213.5 → NP_757362.1 T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

See identical proteins and their annotated locations for NP_757362.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AW296309, BC100912, BC100913, DC405359

Consensus CDS

CCDS1995.1

UniProtKB/TrEMBL

B4E0F8, E7EPH5

Related

ENSP00000331172.2, ENST00000331469.6

Conserved Domains (1) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

86815369..86861886 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011533164.3 → XP_011531466.1 T-cell surface glycoprotein CD8 beta chain isoform X1

See identical proteins and their annotated locations for XP_011531466.1

UniProtKB/TrEMBL

B4E0F8, E7EPH5, E9PD41, Q53QL8

Conserved Domains (2) summary

cd07700
Location:29 → 134

IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

smart00410
Location:26 → 134

IG_like; Immunoglobulin like

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

86817280..86863804 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344557.1 → XP_054200532.1 T-cell surface glycoprotein CD8 beta chain isoform X1

UniProtKB/TrEMBL

Q53QL8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_172099.2: Suppressed sequence

Description

NM_172099.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NM_172100.1: Suppressed sequence

Description

NM_172100.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.