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    CHN1 chimerin 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698697, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CHN1provided by VGNC
    Official Full Name
    chimerin 1provided by VGNC
    Primary source
    VGNC:VGNC:71041
    See related
    Ensembl:ENSMMUG00000021797
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CHN1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (61896937..62096240, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (61807007..62006967, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene WAS/WASL interacting protein family member 1 Neighboring gene uncharacterized LOC106992618 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-chimaerin
    Names
    chimerin (chimaerin) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      61896937..62096240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028830854.1 → XP_028686687.1  N-chimaerin isoform X6

      UniProtKB/TrEMBL
      G7N8C7
      Conserved Domains (3) summary
      cd10352
      Location:16 → 102
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:240 → 433
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:175 → 231
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    2. XM_028830851.1 → XP_028686684.1  N-chimaerin isoform X3

      UniProtKB/TrEMBL
      G7N8C7
      Conserved Domains (3) summary
      cd10352
      Location:29 → 115
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:253 → 446
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:188 → 244
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    3. XM_028830852.1 → XP_028686685.1  N-chimaerin isoform X4

      UniProtKB/TrEMBL
      G7N8C7
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:250 → 443
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:193 → 239
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. XM_028830853.1 → XP_028686686.1  N-chimaerin isoform X5

      UniProtKB/TrEMBL
      G7N8C7
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      pfam00130
      Location:216 → 265
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl02570
      Location:276 → 423
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    5. XM_028830850.1 → XP_028686683.1  N-chimaerin isoform X1

      UniProtKB/TrEMBL
      G7N8C7
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:276 → 469
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:216 → 265
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    6. XM_028830856.1 → XP_028686689.1  N-chimaerin isoform X8

      UniProtKB/TrEMBL
      A0A1D5QQJ3
      Related
      ENSMMUP00000050321.2, ENSMMUT00000065320.2
      Conserved Domains (3) summary
      cd04372
      Location:214 → 407
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:154 → 203
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl15255
      Location:1 → 76
      SH2; Src homology 2 (SH2) domain

    7. XM_028830857.1 → XP_028686690.1  N-chimaerin isoform X11

      Related
      ENSMMUP00000050528.2, ENSMMUT00000070634.2
      Conserved Domains (2) summary
      cd04372
      Location:41 → 234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:1 → 32
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    8. XM_015110403.2 → XP_014965889.1  N-chimaerin isoform X10

      UniProtKB/TrEMBL
      F7GRZ6
      Related
      ENSMMUP00000061883.1, ENSMMUT00000100576.1
      Conserved Domains (2) summary
      cd04372
      Location:86 → 279
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:21 → 77
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    9. XM_015110402.2 → XP_014965888.1  N-chimaerin isoform X9

      Conserved Domains (2) summary
      cd04372
      Location:96 → 289
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:36 → 88
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    10. XM_015110400.2 → XP_014965886.1  N-chimaerin isoform X2

      UniProtKB/TrEMBL
      F7ET58, G7N8C7
      Related
      ENSMMUP00000028709.4, ENSMMUT00000030674.4
      Conserved Domains (3) summary
      cd10352
      Location:42 → 128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:266 → 459
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20856
      Location:201 → 257
      C1_alphaCHN; protein kinase C conserved region 1 (C1 domain) found in alpha-chimaerin and similar proteins

    11. XM_028830855.1 → XP_028686688.1  N-chimaerin isoform X7

      UniProtKB/TrEMBL
      F7ESU8, G7N8C7
      Related
      ENSMMUP00000028710.4, ENSMMUT00000030675.4
      Conserved Domains (3) summary
      cd10352
      Location:42 → 128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:240 → 433
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20806
      Location:183 → 231
      C1_CHN; protein kinase C conserved region 1 (C1 domain) found in the chimaerin family
    Nucleotide Protein
    Heading Accession and Version

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