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    OPRL1 opioid related nociceptin receptor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719224, updated on 5-Mar-2024

    Summary

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    Official Symbol
    OPRL1provided by VGNC
    Official Full Name
    opioid related nociceptin receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:97110
    Locus tag
    EGK_02163
    See related
    Ensembl:ENSMMUG00000043739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Summary
    The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (99313412..99328276)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (184589..201011, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A2 Neighboring gene regulator of G protein signaling 19 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene myelin transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates. Cremeans CM, et al. J Pharmacol Exp Ther, 2012 Oct. PMID 22743574, Free PMC Article
    2. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
    3. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coactivation of nociceptin receptors simultaeously with mu opioid receptors plays an innovative role in antinociception.
      Title: Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nociceptin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nociceptin receptor
    Names
    Orphanin FQ receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320614.1 → NP_001307543.1  nociceptin receptor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      JU322449, JV470027, JV508316, JV508317, JV529027, JV602298, JV685421, JV704293
      UniProtKB/TrEMBL
      G7N403
      Related
      ENSMMUP00000044226.2, ENSMMUT00000072361.2
      Conserved Domains (2) summary
      pfam00001
      Location:68 → 319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66 → 188
      7tm_4; Olfactory receptor

    2. NM_001320615.1 → NP_001307544.1  nociceptin receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      JU322449, JV470027, JV508316, JV508317, JV529027, JV602298, JV685421, JV704293
      UniProtKB/TrEMBL
      H9EUZ6
      Conserved Domains (2) summary
      pfam00001
      Location:68 → 319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66 → 188
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      99313412..99328276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028827446.1 → XP_028683279.1  nociceptin receptor isoform X1

      UniProtKB/TrEMBL
      H9EUZ6
      Conserved Domains (1) summary
      cd15092
      Location:52 → 330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_028827447.1 → XP_028683280.1  nociceptin receptor isoform X2

      Conserved Domains (3) summary
      pfam12815
      Location:11 → 57
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      cd14964
      Location:58 → 79
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:46 → 301
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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