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    Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 320207, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pik3r5provided by MGI
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 5provided by MGI
    Primary source
    MGI:MGI:2443588
    See related
    Ensembl:ENSMUSG00000020901 AllianceGenome:MGI:2443588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p101; Foap2; F730038I15Rik
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway; positive regulation of MAP kinase activity; and regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in brain and retina nuclear layer. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 27.4), spleen adult (RPKM 14.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pik3r5 in Genome Data Viewer
    Location:
    11 B3; 11 41.69 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68322951..68388675)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68432125..68497849)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29816 Neighboring gene predicted gene, 31954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68245166-68245319 Neighboring gene STARR-positive B cell enhancer mm9_chr11:68245418-68245719 Neighboring gene predicted gene, 32046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68276328-68276529 Neighboring gene STARR-positive B cell enhancer ABC_E3959 Neighboring gene STARR-positive B cell enhancer ABC_E6997 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene STARR-seq mESC enhancer starr_29817 Neighboring gene major facilitator superfamily domain containing 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5. Huang Z, et al. J Muscle Res Cell Motil, 2023 Mar. PMID 36512272
    2. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Suire S, et al. Nat Cell Biol, 2006 Nov. PMID 17041586
    3. Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils. Rynkiewicz NK, et al. Sci Signal, 2020 Nov 3. PMID 33144519, Free PMC Article
    4. The regulatory subunits of PI3Kγ control distinct neutrophil responses. Deladeriere A, et al. Sci Signal, 2015 Jan 20. PMID 25605974
    5. Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. Janas ML, et al. J Exp Med, 2010 Jan 18. PMID 20038597, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
      Title: lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
    2. Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
      Title: Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5.
    3. Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
      Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 5
    Names
    PI3-kinase p101 subunit
    PI3-kinase regulatory subunit 5
    p101-PI3K
    phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
    phosphoinositide-3-kinase, regulatory subunit 5, p101
    ptdIns-3-kinase p101
    ptdIns-3-kinase regulatory subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177320.2 → NP_796294.2  phosphoinositide 3-kinase regulatory subunit 5

      See identical proteins and their annotated locations for NP_796294.2

      Status: VALIDATED

      Source sequence(s)
      AK089483, AK149847, AL606831
      Consensus CDS
      CCDS24865.1
      UniProtKB/Swiss-Prot
      Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7
      UniProtKB/TrEMBL
      A1A4T4
      Related
      ENSMUSP00000021283.8, ENSMUST00000021283.8
      Conserved Domains (1) summary
      pfam10486
      Location:6 → 871
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68322951..68388675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533548.3 → XP_006533611.1  phosphoinositide 3-kinase regulatory subunit 5 isoform X1

      See identical proteins and their annotated locations for XP_006533611.1

      UniProtKB/Swiss-Prot
      Q3TU01, Q3UDZ2, Q5SW28, Q8C215, Q8CGQ7
      UniProtKB/TrEMBL
      A1A4T4
      Conserved Domains (1) summary
      pfam10486
      Location:6 → 871
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW28.1 GenPept UniProtKB/Swiss-Prot:Q5SW28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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