Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3r6provided by MGI
Official Full Name: phosphoinositide-3-kinase regulatory subunit 5provided by MGI
Primary source: MGI:MGI:2144613
See related: Ensembl:ENSMUSG00000046207 AllianceGenome:MGI:2144613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p84; p87PIKAP; p84 PIKAP; p87(PIKAP)
Summary: Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in lung adult (RPKM 5.1), mammary gland adult (RPKM 3.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 41.76 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68393845..68443524)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (68503019..68552698)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
These data demonstrate PI3Kgamma-dependent signalling downstream of IL-17RA, which plays a pivotal role in regulating IL-17 production in T cells.
Title: Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
that genetic deletion of PI3Kgamma enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2)-dependent itch.
Title: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ).
Results suggest that the CXCR2 and PI3Kgamma signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
Title: A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.
PI3Kgamma has a role in the induction of CXCR3 on T cells
Title: PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
Title: Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.
p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
Title: Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit277 (e-PCR), detects polymorphism
- UniSTS:126481

BB220380 (e-PCR)
- UniSTS:185888

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IB	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoinositide 3-kinase regulatory subunit 6

Names: p84 PI3K adapter protein; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein; phosphoinositide 3-kinase gamma adapter protein of 87 kDa; phosphoinositide-3-kinase, regulatory subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004435.3 → NP_001004435.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 2

See identical proteins and their annotated locations for NP_001004435.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK153039, AY753194, BX629873, BY202586

Consensus CDS

CCDS24866.1

UniProtKB/Swiss-Prot

Q3U6Q4

Related

ENSMUSP00000099673.2, ENSMUST00000102613.8

Conserved Domains (1) summary

pfam10486
Location:34 → 749

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
NM_001081566.2 → NP_001075035.1 phosphoinositide 3-kinase regulatory subunit 6 isoform 1

See identical proteins and their annotated locations for NP_001075035.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform 1.

Source sequence(s)

AK153039, BX629873, BY202586

Consensus CDS

CCDS36186.1

UniProtKB/Swiss-Prot

Q3TBT5, Q3U6Q4, Q3UAY4, Q8K323

Related

ENSMUSP00000052522.7, ENSMUST00000060441.7

Conserved Domains (1) summary

pfam10486
Location:34 → 753

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

NR_126153.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in an internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK036623, AK151178, BX629873, BY202586

Related

ENSMUST00000153671.8
NR_126154.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses alternate splice sites in two internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK036623, AK151178, AK153039, AL606831, BX629873, BY202586

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

68393845..68443524

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314217.2 → XP_017169706.1 phosphoinositide 3-kinase regulatory subunit 6 isoform X2

Conserved Domains (1) summary

pfam10486
Location:32 → 546

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
XM_006531950.1 → XP_006532013.1 phosphoinositide 3-kinase regulatory subunit 6 isoform X3

Conserved Domains (1) summary

pfam10486
Location:32 → 499

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
XM_006531948.1 → XP_006532011.1 phosphoinositide 3-kinase regulatory subunit 6 isoform X1

Conserved Domains (1) summary

pfam10486
Location:38 → 716

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
XM_030245460.1 → XP_030101320.1 phosphoinositide 3-kinase regulatory subunit 6 isoform X4

Conserved Domains (1) summary

pfam10486
Location:35 → 394

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit