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    Tmem138 transmembrane protein 138 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361728, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem138provided by RGD
    Official Full Name
    transmembrane protein 138provided by RGD
    Primary source
    RGD:735168
    See related
    AllianceGenome:RGD:735168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cilium assembly. Predicted to be located in vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 35.5), Lung (RPKM 23.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216644047..216651091, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207219113..207226159, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226623861..226630911, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase and FMN cyclase Neighboring gene damage-specific DNA binding protein 1 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen A5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Lee JH, et al. Science, 2012 Feb 24. PMID 22282472, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73003

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 138

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198777.2 → NP_942072.2  transmembrane protein 138

      See identical proteins and their annotated locations for NP_942072.2

      Status: VALIDATED

      Source sequence(s)
      BC061578, BF282432
      UniProtKB/Swiss-Prot
      B1WBM3
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216644047..216651091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231047.4 → XP_006231109.1  transmembrane protein 138 isoform X2

      See identical proteins and their annotated locations for XP_006231109.1

      Conserved Domains (1) summary
      pfam14935
      Location:6 → 124
      TMEM138; Transmembrane protein 138

    2. XM_006231046.3 → XP_006231108.1  transmembrane protein 138 isoform X1

      See identical proteins and their annotated locations for XP_006231108.1

      UniProtKB/Swiss-Prot
      B1WBM3
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138

    3. XM_017589444.3 → XP_017444933.1  transmembrane protein 138 isoform X2

      Conserved Domains (1) summary
      pfam14935
      Location:6 → 124
      TMEM138; Transmembrane protein 138

    4. XM_017589443.3 → XP_017444932.1  transmembrane protein 138 isoform X1

      UniProtKB/Swiss-Prot
      B1WBM3
      Conserved Domains (1) summary
      pfam14935
      Location:38 → 156
      TMEM138; Transmembrane protein 138
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WBM3.1 GenPept UniProtKB/Swiss-Prot:B1WBM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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