Rab11a RAB11a, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab11aprovided by RGD
Official Full Name: RAB11a, member RAS oncogene familyprovided by RGD
Primary source: RGD:619762
See related: Ensembl:ENSRNOG00000011302 AllianceGenome:RGD:619762
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of protein localization to plasma membrane; and regulation of long-term neuronal synaptic plasticity. Located in postsynaptic recycling endosome and transport vesicle. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Orthologous to human RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 466.1), Kidney (RPKM 461.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (74118922..74141760, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (65223698..65246461, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (70192975..70215719, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA.
Title: Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA.
Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
Title: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
Which bridges Myo5b and the membrane-bound Rab11a.
Title: Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2.
The Rab11 effector SH3TC2 associates with integrin-alpha 6, which is expressed in myelinating Schwann cells.
Title: Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-α6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.
With neuronal maturity rab11 vesicles (which carry many molecules involved in axon growth) became selectively targeted to the somatodendritic compartment and excluded from axons by predominant retrograde transport contributing to regeneration decline.
Title: Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
Rab8a or Rab11a might be involved in the formation of tunneling nanotubes structures in the peripheral nerve system.
Title: Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes.
the Heparan sulfate proteoglycans-positive vesicular fractions, distinct from plasma membrane-derived material, were enriched in endocytic marker, Rab11.
Title: Characterization of Heparan Sulfate Proteoglycan-positive Recycling Endosomes Isolated from Glioma Cells.
miR-21 inhibited autophagy by targeting the Rab11a 3'UTR in renal ischemia reperfusion injury.
Title: MiR-21 inhibits autophagy by targeting Rab11a in renal ischemia/reperfusion.
Data indicate that internalized dopamine transporter (DAT) colocalized with GFP-Rab11 and suggest that Rab11 plays an important role in the recycling of DAT following AMPH-induced DAT down-regulation.
Title: Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.
Results indicate that Rab11a, Rab8a, and Myo5B function as part of a network to promote stretch-induced exocytosis.
Title: A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dynein light intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables dynein light intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome transport	IEA Inferred from Electronic Annotation more info
involved_in melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in multivesicular body assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to recycling endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multivesicular body size	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to centrosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endosomal processing	EXP Inferred from Experiment more info	PubMed
involved_in synaptic vesicle endosomal processing	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endosomal processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic endosome	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic endosome	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-11A

Names: 24KG; rab-11

NP_112414.1

EC 3.6.5.2

XP_063122287.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.