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    Csnk2a2 casein kinase 2 alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307641, updated on 2-May-2024

    Summary

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    Official Symbol
    Csnk2a2provided by RGD
    Official Full Name
    casein kinase 2 alpha 2provided by RGD
    Primary source
    RGD:1306882
    See related
    AllianceGenome:RGD:1306882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein N-terminus binding activity and protein serine/threonine kinase activity. Involved in cerebral cortex development; liver regeneration; and spermatogenesis. Located in several cellular components, including acrosomal vesicle; chromatin; and nucleus. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 73.2), Thymus (RPKM 73.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csnk2a2 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9562340..9602136)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9556443..9596080)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9972537..10012043)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098510 Neighboring gene serine protease 54 Neighboring gene coiled-coil domain containing 113 Neighboring gene cilia and flagella associated protein 20 Neighboring gene matrix metallopeptidase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. Orlandini M, et al. J Biol Chem, 1998 Aug 14. PMID 9694889
    2. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Alvarado-Díaz CP, et al. Cell Tissue Res, 2009 Oct. PMID 19711102
    3. The TRAIL to selective tumor death. French LE, et al. Nat Med, 1999 Feb. PMID 9930856
    4. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin. Kulikova OG, et al. Biochemistry (Mosc), 1998 Dec. PMID 9916157
    5. The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory beta-subunit. Sarrouilhe D, et al. Biochim Biophys Acta, 1998 Jun 22. PMID 9630630

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase II subunit alpha'
    Names
    casein kinase 2, alpha prime polypeptide
    casein kinase II, alpha 2, polypeptide
    NP_001100879.1
    XP_038953618.1
    XP_038953619.1
    XP_038953620.1
    XP_038953621.1
    XP_038953622.1
    XP_038953623.1
    XP_063134049.1
    XP_063134050.1
    XP_063134051.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107409.1 → NP_001100879.1  casein kinase II subunit alpha'

      See identical proteins and their annotated locations for NP_001100879.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474006
      UniProtKB/TrEMBL
      A6JY05, B4F7A9
      Conserved Domains (2) summary
      cd14132
      Location:22 → 326
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
      pfam00069
      Location:40 → 325
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9562340..9602136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097690.2 → XP_038953618.1  casein kinase II subunit alpha' isoform X1

      UniProtKB/TrEMBL
      B4F7A9
      Conserved Domains (1) summary
      cd14132
      Location:22 → 309
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    2. XM_039097692.2 → XP_038953620.1  casein kinase II subunit alpha' isoform X3

      UniProtKB/TrEMBL
      B4F7A9
      Conserved Domains (1) summary
      cd14132
      Location:22 → 281
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    3. XM_039097694.2 → XP_038953622.1  casein kinase II subunit alpha' isoform X6

      Conserved Domains (1) summary
      cd14132
      Location:22 → 247
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    4. XM_063277980.1 → XP_063134050.1  casein kinase II subunit alpha' isoform X5

    5. XM_063277979.1 → XP_063134049.1  casein kinase II subunit alpha' isoform X5

    6. XM_039097691.2 → XP_038953619.1  casein kinase II subunit alpha' isoform X2

      UniProtKB/TrEMBL
      B4F7A9
      Conserved Domains (1) summary
      cd14132
      Location:22 → 298
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    7. XM_039097693.2 → XP_038953621.1  casein kinase II subunit alpha' isoform X4

      UniProtKB/TrEMBL
      B4F7A9
      Conserved Domains (1) summary
      cd14132
      Location:22 → 275
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    8. XM_063277981.1 → XP_063134051.1  casein kinase II subunit alpha' isoform X5

    9. XM_039097695.2 → XP_038953623.1  casein kinase II subunit alpha' isoform X5

      Conserved Domains (1) summary
      cd14132
      Location:1 → 189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    Nucleotide Protein Strain
    Heading Accession and Version

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