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    Fkbp15 FKBP prolyl isomerase family member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362528, updated on 13-Apr-2024

    Summary

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    Symbol
    Fkbp15provided by RGD
    Full Name
    FKBP prolyl isomerase family member 15provided by RGD
    Primary source
    RGD:1304816
    See related
    Ensembl:ENSRNOG00000024663 AllianceGenome:RGD:1304816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304816
    Summary
    Predicted to be located in several cellular components, including actin cytoskeleton; axon; and endosome. Predicted to be active in growth cone. Orthologous to human FKBP15 (FKBP prolyl isomerase family member 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 142.7), Thymus (RPKM 105.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80766356..80830622, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75750786..75815038, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78133357..78229311, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478995 Neighboring gene solute carrier family 31 member 2 Neighboring gene solute carrier family 31 member 1 Neighboring gene cell division cycle 26 Neighboring gene pre-mRNA splicing tri-snRNP complex factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. Nakajima O, et al. Biochem Biophys Res Commun, 2006 Jul 21. PMID 16756961
    2. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Harbour ME, et al. Biochem J, 2012 Feb 15. PMID 22070227
    3. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FK506-binding protein 15
    Names
    FK506 binding protein 15
    FK506-binding protein 15-like
    FKBP prolyl isomerase 15
    NP_001414301.1
    XP_038966989.1
    XP_038966990.1
    XP_063144004.1
    XP_063144005.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427372.1 → NP_001414301.1  FK506-binding protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A7U0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      80766356..80830622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111062.2 → XP_038966990.1  FK506-binding protein 15 isoform X4

      UniProtKB/TrEMBL
      A6J7T8
      Conserved Domains (4) summary
      PHA03247
      Location:934 → 1105
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:560 → 879
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:397 → 494
      PRK10263; DNA translocase FtsK; Provisional
      pfam00254
      Location:193 → 286
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. XM_039111061.2 → XP_038966989.1  FK506-binding protein 15 isoform X3

      UniProtKB/TrEMBL
      A6J7T8
      Related
      ENSRNOP00000089691.1
      Conserved Domains (4) summary
      PHA03247
      Location:944 → 1115
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:560 → 889
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:397 → 494
      PRK10263; DNA translocase FtsK; Provisional
      pfam00254
      Location:193 → 286
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    3. XM_063287935.1 → XP_063144005.1  FK506-binding protein 15 isoform X2

    4. XM_063287934.1 → XP_063144004.1  FK506-binding protein 15 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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