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    Csrnp3 cysteine and serine rich nuclear protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311093, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Csrnp3provided by RGD
    Official Full Name
    cysteine and serine rich nuclear protein 3provided by RGD
    Primary source
    RGD:1306214
    See related
    Ensembl:ENSRNOG00000005359 AllianceGenome:RGD:1306214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Csnrp3; RGD1306214
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 90.1), Adrenal (RPKM 29.7) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (70906587..71102596)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (50498379..50695598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (51883559..52120290)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486370 Neighboring gene trichohyalin-like Neighboring gene uncharacterized LOC134486371 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene uncharacterized LOC134486372 Neighboring gene tetratricopeptide repeat domain 21B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Taip2 is a novel cell death-related gene expressed in the brain during development. Yamada K, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18291095
    2. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
    3. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine/serine-rich nuclear protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271225.1 → NP_001258154.1  cysteine/serine-rich nuclear protein 3

      See identical proteins and their annotated locations for NP_001258154.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HLX7, D4AE74
      Related
      ENSRNOP00000007197.8, ENSRNOT00000007197.8
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      70906587..71102596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104838.2 → XP_038960766.1  cysteine/serine-rich nuclear protein 3 isoform X2

      UniProtKB/TrEMBL
      A6HLX7, D4AE74
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. XM_039104839.2 → XP_038960767.1  cysteine/serine-rich nuclear protein 3 isoform X2

      UniProtKB/TrEMBL
      A6HLX7, D4AE74
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    3. XM_039104840.2 → XP_038960768.1  cysteine/serine-rich nuclear protein 3 isoform X3

      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. XM_039104837.2 → XP_038960765.1  cysteine/serine-rich nuclear protein 3 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:111 → 328
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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