ADGRE3 adhesion G protein-coupled receptor E3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRE3provided by HGNC
Official Full Name: adhesion G protein-coupled receptor E3provided by HGNC
Primary source: HGNC:HGNC:23647
See related: Ensembl:ENSG00000131355 MIM:606101; AllianceGenome:HGNC:23647
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EMR3
Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Expression: Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14600117..14674844, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14728189..14801146, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14729929..14785656, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
Title: [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target.
Title: EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target.
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3.
Title: Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.
The expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes.
Title: The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs	PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Markers

WI-18295 (e-PCR)
- UniSTS:8704

NoName (e-PCR)
- UniSTS:494632

SHGC-145980 (e-PCR)
- UniSTS:174915

RH47472 (e-PCR)
- UniSTS:84058

D10S16 (e-PCR)
- UniSTS:155756

GDB:181546 (e-PCR)
- UniSTS:155272

RH47140 (e-PCR)
- UniSTS:89260

SHGC-147047 (e-PCR)
- UniSTS:175577

PMC59887P1 (e-PCR)
- UniSTS:273375

RH40308 (e-PCR)
- UniSTS:92921

G59806 (e-PCR)
- UniSTS:136955

SHGC-32719 (e-PCR)
- UniSTS:167675

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor E3

Names: EGF-like module receptor 3; EGF-like module-containing mucin-like hormone receptor-like 3; egf-like module containing, mucin-like, hormone receptor-like 3; egf-like module-containing mucin-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289158.2 → NP_001276087.1 adhesion G protein-coupled receptor E3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001276087.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AF239764, AK298653, AL832663, AY358817, BC128053

Consensus CDS

CCDS74297.1

UniProtKB/TrEMBL

A8K4E4

Related

ENSP00000340758.4, ENST00000344373.8

Conserved Domains (2) summary

pfam01825
Location:252 → 292

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:301 → 542

7tm_4; Olfactory receptor
NM_001289159.2 → NP_001276088.1 adhesion G protein-coupled receptor E3 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.

Source sequence(s)

AF239764, AK298653, BC128053

Consensus CDS

CCDS74296.1

UniProtKB/TrEMBL

B7Z5A1, E7EW83

Related

ENSP00000396208.2, ENST00000443157.6

Conserved Domains (2) summary

pfam01825
Location:178 → 218

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:227 → 468

7tm_4; Olfactory receptor
NM_032571.5 → NP_115960.2 adhesion G protein-coupled receptor E3 isoform 1 precursor

See identical proteins and their annotated locations for NP_115960.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF239764, AK298653, AL832663, BC121130, BC128053

Consensus CDS

CCDS12315.1

UniProtKB/Swiss-Prot

Q9BY15

UniProtKB/TrEMBL

A8K4E4

Related

ENSP00000253673.4, ENST00000253673.6

Conserved Domains (3) summary

cd00054
Location:67 → 104

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01825
Location:304 → 344

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:353 → 594

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

14600117..14674844 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528374.3 → XP_011526676.1 adhesion G protein-coupled receptor E3 isoform X1

UniProtKB/TrEMBL

A8K4E4

Conserved Domains (3) summary

cd00054
Location:50 → 87

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01825
Location:287 → 327

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:336 → 577

7tm_4; Olfactory receptor
XM_047439546.1 → XP_047295502.1 adhesion G protein-coupled receptor E3 isoform X2

RNA

XR_001753772.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

14728189..14801146 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322398.1 → XP_054178373.1 adhesion G protein-coupled receptor E3 isoform X1
XM_054322399.1 → XP_054178374.1 adhesion G protein-coupled receptor E3 isoform X2

RNA

XR_008485210.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152939.1: Suppressed sequence

Description

NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.