Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb1aprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B, member 1aprovided by MGI
Primary source: MGI:MGI:1913472
See related: Ensembl:ENSMUSG00000044734 AllianceGenome:MGI:1913472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EI; EIA; LEI; PI2; MNEI; M/NEI; ELANH2; 1190005M04Rik
Summary: Predicted to enable peptidase inhibitor activity. Predicted to contribute to serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of interleukin-1 beta production; regulation of innate immune response; and type B pancreatic cell proliferation. Acts upstream of or within regulation of protein catabolic process. Located in extracellular region. Is expressed in bladder wall; brain; embryo mesenchyme; gut; and liver lobe. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 90.3), duodenum adult (RPKM 21.7) and 10 other tissues See more
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Genomic context

Location:: 13 A3.2; 13 13.75 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (33026075..33037189, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (32842092..32853206, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.
Title: Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.
These results indicate that liver FoxO1 promotes serpinB1 expression in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent effects on serpinB1 expression in the liver.
Title: Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion.
SerpinB1 is a conserved endogenous secretory protein that promotes proliferation of beta cells.
Title: SerpinB1 Promotes Pancreatic β Cell Proliferation.
our findings reveal a novel function of serpinB1 in limiting untoward expansion of lymphocytes with a Th17 phenotype.
Title: SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells.
SerpinB1 is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity.
Title: SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G.
Expression of Leukocyte elastase inhibitor in the ovary and oviduct of infected VDR(+/+) mice was greater than that of infected VDR(-/-) mice.
Title: Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489539

AI325983 (e-PCR)
- UniSTS:165865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in type B pancreatic cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukocyte elastase inhibitor A

Names: ovalbumin; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1a; serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025429.2 → NP_079705.2 leukocyte elastase inhibitor A

See identical proteins and their annotated locations for NP_079705.2

Status: VALIDATED

Source sequence(s)

AI325983, AK160167, BY266933

Consensus CDS

CCDS26428.1

UniProtKB/Swiss-Prot

Q3TV23, Q5SUV7, Q9D0S8, Q9D154, Q9D7S8

UniProtKB/TrEMBL

Q8BK60

Related

ENSMUSP00000075690.7, ENSMUST00000076352.8

Conserved Domains (1) summary

cd19560
Location:1 → 379

serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

33026075..33037189 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247348.2 → XP_030103208.1 leukocyte elastase inhibitor A isoform X1

UniProtKB/Swiss-Prot

Q3TV23, Q5SUV7, Q9D0S8, Q9D154, Q9D7S8

UniProtKB/TrEMBL

Q8BK60

Conserved Domains (1) summary

cd19560
Location:1 → 379

serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)
XM_006516724.3 → XP_006516787.1 leukocyte elastase inhibitor A isoform X1

See identical proteins and their annotated locations for XP_006516787.1

UniProtKB/Swiss-Prot

Q3TV23, Q5SUV7, Q9D0S8, Q9D154, Q9D7S8

UniProtKB/TrEMBL

Q8BK60

Conserved Domains (1) summary

cd19560
Location:1 → 379

serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)