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    Pdf peptide deformylase (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 68023, updated on 30-Apr-2024

    Summary

    Official Symbol
    Pdfprovided by MGI
    Official Full Name
    peptide deformylase (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1915273
    See related
    Ensembl:ENSMUSG00000078931 AllianceGenome:MGI:1915273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019N19Rik
    Summary
    Predicted to enable peptide deformylase activity. Predicted to be involved in cellular protein modification process and positive regulation of cell population proliferation. Predicted to be active in mitochondrion. Orthologous to human PDF (peptide deformylase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 65.3), ovary adult (RPKM 44.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Pdf in Genome Data Viewer
    Location:
    8 D3; 8 53.55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107772921..107775246, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107046289..107048614, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3803 Neighboring gene predicted gene 16208 Neighboring gene vacuolar protein sorting 4A Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene component of oligomeric golgi complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E3804 Neighboring gene NIP7, nucleolar pre-rRNA processing protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide deformylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide deformylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-terminal protein amino acid modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in co-translational protein modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-methionine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-methionine modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptide deformylase, mitochondrial
    Names
    peptide deformylase-like protein
    polypeptide deformylase
    NP_080789.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026513.2NP_080789.2  peptide deformylase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AI447856, AK008820, AV099506, BB658019
      Consensus CDS
      CCDS59743.1
      UniProtKB/Swiss-Prot
      S4R2K0
      Related
      ENSMUSP00000138676.2, ENSMUST00000055316.10
      Conserved Domains (1) summary
      cd00487
      Location:55212
      Pep_deformylase; Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107772921..107775246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)