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    Jchain immunoglobulin joining chain [ Mus musculus (house mouse) ]

    Gene ID: 16069, updated on 16-Oct-2021

    Summary

    Official Symbol
    Jchainprovided by MGI
    Official Full Name
    immunoglobulin joining chainprovided by MGI
    Primary source
    MGI:MGI:96493
    See related
    Ensembl:ENSMUSG00000067149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igj; Jch; AI323815; 9530090F24Rik
    Expression
    Biased expression in large intestine adult (RPKM 384.0), small intestine adult (RPKM 358.4) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Jchain in Genome Data Viewer
    Location:
    5; 5 E1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88667668..88675756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88519809..88527897, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (88948834..88956922, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ameloblastin Neighboring gene enamelin Neighboring gene UTP3 small subunit processome component Neighboring gene predicted gene, 42107 Neighboring gene RUN and FYVE domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables IgA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antigen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptidoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of dimeric IgA immunoglobulin complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of dimeric IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of monomeric IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pentameric IgM immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of pentameric IgM immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of secretory IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of secretory dimeric IgA immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    immunoglobulin J chain
    Names
    J chain
    immunoglobulin joining gene (not J region)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152839.3NP_690052.2  immunoglobulin J chain precursor

      See identical proteins and their annotated locations for NP_690052.2

      Status: VALIDATED

      Source sequence(s)
      AA254605, AC121585, AK078865, AK160344, BG147365
      Consensus CDS
      CCDS19401.1
      UniProtKB/Swiss-Prot
      P01592
      Related
      ENSMUSP00000084259.4, ENSMUST00000087033.6
      Conserved Domains (1) summary
      pfam15097
      Location:23159
      Ig_J_chain; Immunoglobulin J chain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      88667668..88675756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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