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    Msl3l2 MSL3 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 73390, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Msl3l2provided by MGI
    Official Full Name
    MSL3 like 2provided by MGI
    Primary source
    MGI:MGI:1920640
    See related
    Ensembl:ENSMUSG00000047669 AllianceGenome:MGI:1920640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700060H10Rik
    Summary
    Predicted to enable DNA binding activity; histone acetyltransferase activity (H4-K16 specific); and methylated histone binding activity. Predicted to be involved in heterochromatin assembly and histone modification. Predicted to be located in nucleus. Predicted to be part of MSL complex and NuA4 histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to several human genes including MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 35.3), ovary adult (RPKM 7.3) and 14 other tissues See more
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    Genomic context

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    See Msl3l2 in Genome Data Viewer
    Location:
    10 B3; 10 28.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (55959931..55992976)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (56083835..56116880)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31849 Neighboring gene putative heat shock protein HSP 90-beta-3 Neighboring gene STARR-seq mESC enhancer starr_26716 Neighboring gene STARR-seq mESC enhancer starr_26717 Neighboring gene STARR-seq mESC enhancer starr_26718 Neighboring gene STARR-seq mESC enhancer starr_26719 Neighboring gene STARR-seq mESC enhancer starr_26720 Neighboring gene STARR-seq mESC enhancer starr_26721 Neighboring gene STARR-seq mESC enhancer starr_26722 Neighboring gene TBC1 domain family, member 32 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55826518-55826701 Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene STARR-positive B cell enhancer ABC_E8334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:55948756-55948865 Neighboring gene STARR-seq mESC enhancer starr_26724 Neighboring gene STARR-seq mESC enhancer starr_26725 Neighboring gene STARR-seq mESC enhancer starr_26726 Neighboring gene STARR-seq mESC enhancer starr_26730 Neighboring gene STARR-seq mESC enhancer starr_26731 Neighboring gene STARR-seq mESC enhancer starr_26732 Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene gap junction protein, alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    male-specific lethal 3-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163833.1 → NP_001157305.1  male-specific lethal 3-like 2

      See identical proteins and their annotated locations for NP_001157305.1

      Status: VALIDATED

      Source sequence(s)
      AC153521
      Consensus CDS
      CCDS48561.1
      UniProtKB/TrEMBL
      G3X992, Q3U2B0
      Related
      ENSMUSP00000051220.8, ENSMUST00000063138.8
      Conserved Domains (1) summary
      pfam05712
      Location:33 → 356
      MRG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      55959931..55992976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512876.4 → XP_006512939.1  male-specific lethal 3-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006512939.1

      UniProtKB/TrEMBL
      G3X992, Q3U2B0
      Conserved Domains (1) summary
      pfam05712
      Location:33 → 356
      MRG

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133751.1: Suppressed sequence

      Description
      NM_133751.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

    2. NR_003618.1: Suppressed sequence

      Description
      NR_003618.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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