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    Man2a2 mannosidase 2, alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 140481, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Man2a2provided by MGI
    Official Full Name
    mannosidase 2, alpha 2provided by MGI
    Primary source
    MGI:MGI:2150656
    See related
    Ensembl:ENSMUSG00000038886 AllianceGenome:MGI:2150656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MX; Man IIx; 1700052O22Rik; 4931438M07Rik
    Summary
    Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Predicted to be involved in N-glycan processing and protein deglycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in olfactory epithelium; retina outer nuclear layer; skeletal muscle; and vomeronasal organ. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 32.8), mammary gland adult (RPKM 28.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D2; 7 45.65 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79998843..80021222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80349095..80371483, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo role of alpha-mannosidase IIx: ineffective spermatogenesis resulting from targeted disruption of the Man2a2 in the mouse. Fukuda MN, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417422
    2. N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay. Akama TO, et al. Methods Enzymol, 2006. PMID 17113875
    3. Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Akama TO, et al. Science, 2002 Jan 4. PMID 11778047
    4. Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Hiramoto S, et al. Biochem Biophys Res Commun, 1997 Dec 18. PMID 9425289
    5. Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Akama TO, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754854, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MX was produced by transfecting mammalian cells with expression vectors and the substrate specificity of MX was determined.
      Title: N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.
    2. Data show that either alpha-Mannosidase II or IIX can biochemically compensate for the deficiency of the other in vivo, and either of two is required for late embryonic and early postnatal development.
      Title: Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.
    3. Man2a2 null spermatogenic cells fail to adhere to Sertoli cells and are prematurely released from the testis to epididymis
      Title: Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing N-glycosyl compounds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase 2x
    Names
    alpha-mannosidase IIx
    mannosidase, alpha, class 2A, member 2
    mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
    NP_766491.2
    XP_006540662.1
    XP_036008560.1
    XP_036008561.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172903.4 → NP_766491.2  alpha-mannosidase 2x

      See identical proteins and their annotated locations for NP_766491.2

      Status: VALIDATED

      Source sequence(s)
      AC136740, AK029913, BC055006, CJ105476
      Consensus CDS
      CCDS57556.1
      UniProtKB/Swiss-Prot
      Q3UVK1, Q8BRK9
      UniProtKB/TrEMBL
      Q197W7
      Related
      ENSMUSP00000095949.4, ENSMUST00000098346.5
      Conserved Domains (1) summary
      PLN02701
      Location:140 → 1151
      PLN02701; alpha-mannosidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79998843..80021222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152667.1 → XP_036008560.1  alpha-mannosidase 2x isoform X1

      UniProtKB/Swiss-Prot
      Q3UVK1, Q8BRK9
      UniProtKB/TrEMBL
      Q197W7
      Conserved Domains (1) summary
      PLN02701
      Location:140 → 1151
      PLN02701; alpha-mannosidase

    2. XM_006540599.4 → XP_006540662.1  alpha-mannosidase 2x isoform X1

      See identical proteins and their annotated locations for XP_006540662.1

      UniProtKB/Swiss-Prot
      Q3UVK1, Q8BRK9
      UniProtKB/TrEMBL
      Q197W7
      Conserved Domains (1) summary
      PLN02701
      Location:140 → 1151
      PLN02701; alpha-mannosidase

    3. XM_036152668.1 → XP_036008561.1  alpha-mannosidase 2x isoform X2

      UniProtKB/TrEMBL
      Q7TPQ0
      Conserved Domains (1) summary
      PLN02701
      Location:4 → 527
      PLN02701; alpha-mannosidase

    RNA

    1. XR_003946387.2 RNA Sequence

    2. XR_001785475.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRK9.2 GenPept UniProtKB/Swiss-Prot:Q8BRK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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