Elavl3 ELAV like RNA binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elavl3provided by MGI
Official Full Name: ELAV like RNA binding protein 3provided by MGI
Primary source: MGI:MGI:109157
See related: Ensembl:ENSMUSG00000003410 AllianceGenome:MGI:109157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Huc; mHuC; PLE21; 2600009P04Rik
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be part of ribonucleoprotein complex. Is expressed in central nervous system; enteric nervous system; intestine; primitive bladder; and sensory organ. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 68.0), whole brain E14.5 (RPKM 67.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 8.07 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21926301..21963442, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (22015005..22052146, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Elavl3 is associated with slowly progressive motor deficits leading to severe cerebellar ataxia.
Title: Elavl3 is essential for the maintenance of Purkinje neuron axons.
Results suggested that exon 34 of AnkyrinG is an embryonic-stage-preferential exon that should be excluded from mature neurons and that Elavl3 regulates neuronal polarity through alternative splicing of this exon.
Title: Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG.
This genome-wide approaches identify in vivo targets and functions of nElavl proteins in regulating brain RNA and excitability.
Title: Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.
The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236079

Elavl3 (e-PCR), detects polymorphism
- UniSTS:479107

D9Bwg1e (e-PCR), detects polymorphism
- UniSTS:142744

D4S2983 (e-PCR)
- UniSTS:74945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELAV-like protein 3

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); HU-antigen C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.