U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrrc59 leucine rich repeat containing 59 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287633, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrrc59provided by RGD
    Official Full Name
    leucine rich repeat containing 59provided by RGD
    Primary source
    RGD:1305092
    See related
    Ensembl:ENSRNOG00000003524 AllianceGenome:RGD:1305092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Predicted to be located in endoplasmic reticulum and mitochondrial nucleoid. Orthologous to human LRRC59 (leucine rich repeat containing 59). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 397.7), Thymus (RPKM 363.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80069162..80083820)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79572295..79586953)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82352390..82367047)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene chondroadherin Neighboring gene uncharacterized LOC102555790 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily. Ohsumi T, et al. Biochem J, 1993 Sep 1. PMID 7690545, Free PMC Article
    2. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578
    3. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC105677

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeat-containing protein 59
    Names
    protein p34

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008280.1 → NP_001008281.1  leucine-rich repeat-containing protein 59

      See identical proteins and their annotated locations for NP_001008281.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086530
      UniProtKB/Swiss-Prot
      Q5RJR8, Q63742
      UniProtKB/TrEMBL
      A0A8I6AVN3, A6HI59
      Related
      ENSRNOP00000004941.2, ENSRNOT00000004941.5
      Conserved Domains (3) summary
      COG4886
      Location:18 → 120
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:19 → 40
      LRR_1; leucine-rich repeat [structural motif]
      cl30717
      Location:135 → 243
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      80069162..80083820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJR8.1 GenPept UniProtKB/Swiss-Prot:Q5RJR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous