Acat2 acetyl-CoA acetyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Acat2provided by RGD
Full Name: acetyl-CoA acetyltransferase 2provided by RGD
Primary source: RGD:1359366
See related: Ensembl:ENSRNOG00000019189 AllianceGenome:RGD:1359366
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acat3; Ab2-076
Summary: Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including bile acid signaling pathway; ketone body catabolic process; and liver development. Located in cytosol. Biomarker of premature menopause. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 120.4), Brain (RPKM 104.9) and 9 other tissues See more
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Genomic context

Location:: 1q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50100840..50118886)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47695833..47713879)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (47972399..47992654)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increased H3K27me3 expression might cause a disorder of folate metabolic pathway by silencing ACat2 expression, leading to reduced proliferation and differentiation of neural stem cells, and ultimately the occurrence of neural tube defects.
Title: The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat332 (e-PCR), detects polymorphism
- UniSTS:227135

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in dolichol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone body catabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: acetyl-CoA acetyltransferase, cytosolic

Names: acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; cytosolic acetoacetyl-CoA thiolase

NP_001006996.1

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006995.1 → NP_001006996.1 acetyl-CoA acetyltransferase, cytosolic

See identical proteins and their annotated locations for NP_001006996.1

Status: PROVISIONAL

Source sequence(s)

BC083872

UniProtKB/Swiss-Prot

Q5XI22

UniProtKB/TrEMBL

A6KP31, F1LS48

Related

ENSRNOP00000083545.1, ENSRNOT00000114086.1

Conserved Domains (2) summary

PRK05790
Location:8 → 396

PRK05790; putative acyltransferase; Provisional

cd00751
Location:9 → 396

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...