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    Grhpr glyoxylate and hydroxypyruvate reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680021, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Grhprprovided by RGD
    Official Full Name
    glyoxylate and hydroxypyruvate reductaseprovided by RGD
    Primary source
    RGD:1308851
    See related
    Ensembl:ENSRNOG00000012794 AllianceGenome:RGD:1308851
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables carboxylic acid binding activity; nucleotide binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1452.3), Liver (RPKM 1445.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64029856..64039287)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59234179..59243614)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60528981..60538410)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487064 Neighboring gene uncharacterized LOC120102863 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene uncharacterized LOC134486934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coenzyme specificity of mammalian liver D-glycerate dehydrogenase. Van Schaftingen E, et al. Eur J Biochem, 1989 Dec 8. PMID 2689175
    2. A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. Takayama T, et al. Nephrol Dial Transplant, 2007 Aug. PMID 17510093, Free PMC Article
    3. Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth MP, et al. J Mol Biol, 2006 Jun 30. PMID 16756993
    4. Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. Rumsby G, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524214
    5. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Cramer SD, et al. Hum Mol Genet, 1999 Oct. PMID 10484776

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glyoxylate reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroxypyruvate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxypyruvate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dicarboxylic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glyoxylate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glyoxylate reductase/hydroxypyruvate reductase
    NP_001107226.1
    XP_017449109.1
    XP_017449110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113754.1 → NP_001107226.1  glyoxylate reductase/hydroxypyruvate reductase

      See identical proteins and their annotated locations for NP_001107226.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A0A8J8XIM5, B0BN46, E9PSJ6
      Related
      ENSRNOP00000046867.5, ENSRNOT00000051445.7
      Conserved Domains (1) summary
      cd05301
      Location:14 → 326
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64029856..64039287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593621.3 → XP_017449110.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:1 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_017593620.2 → XP_017449109.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:1 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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