Hdac11 histone deacetylase 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hdac11provided by RGD
Official Full Name: histone deacetylase 11provided by RGD
Primary source: RGD:1311706
See related: Ensembl:ENSRNOG00000006824 AllianceGenome:RGD:1311706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone deacetylase activity. Involved in oligodendrocyte development. Located in nucleus. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 355.0), Kidney (RPKM 92.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125203044..125224584)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (123645873..123667407)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (122781095..122798355)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of HDAC11 with acetylated histone H3 markedly increases oligodendrocyte-specific gene expression in developing cells.
Title: Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone deacetylase 11

NP_001100080.2

EC 3.5.1.98

XP_038963301.1

EC 3.5.1.98

XP_038963302.1

EC 3.5.1.98

XP_038963304.1

EC 3.5.1.98

XP_063141890.1

EC 3.5.1.98

XP_063141891.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106610.2 → NP_001100080.2 histone deacetylase 11

See identical proteins and their annotated locations for NP_001100080.2

Status: VALIDATED

Source sequence(s)

BC166430, CN540732

UniProtKB/TrEMBL

B2GUW3, F7EU26

Related

ENSRNOP00000008962.5, ENSRNOT00000008962.7

Conserved Domains (1) summary

cd09993
Location:35 → 319

HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

125203044..125224584

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107373.1 → XP_038963301.1 histone deacetylase 11 isoform X2

Conserved Domains (1) summary

cd09993
Location:7 → 291

HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11
XM_063285821.1 → XP_063141891.1 histone deacetylase 11 isoform X3

UniProtKB/TrEMBL

A0A8I6ALH9
XM_063285820.1 → XP_063141890.1 histone deacetylase 11 isoform X1
XM_039107374.2 → XP_038963302.1 histone deacetylase 11 isoform X2

Conserved Domains (1) summary

cd09993
Location:7 → 291

HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11
XM_039107376.2 → XP_038963304.1 histone deacetylase 11 isoform X4

UniProtKB/TrEMBL

A6IB92

Conserved Domains (1) summary

cl17011
Location:1 → 158

Arginase_HDAC; Arginase-like and histone-like hydrolases