Myo31DF Myosin 31DF [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Myo31DFprovided by FlyBase
Official Full Name: Myosin 31DFprovided by FlyBase
Primary source: FLYBASE:FBgn0086347
Locus tag: Dmel_CG7438
See related: AllianceGenome:FB:FBgn0086347
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7438; Dm IA; Dmel\CG7438; DmIA; DroMIA; IA; mhc1; Mhc1; Myo-IA; Myo1a; Myo1A; myo1D; Myo1D; myo31DF; MyoIA; MYOIA; myoID; MyoID; souther
Summary: Enables microfilament motor activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in digestive tract development; imaginal disc-derived male genitalia morphogenesis; and mesoderm development. Located in cell cortex. Is expressed in several structures, including extended germ band embryo; genital disc; gut; head; and stage 5 embryo. Orthologous to human MYO1D (myosin ID) and MYO1G (myosin IG). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 31F1-31F4; 2-43 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10491814..10506779, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10491814..10506779, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results reveal the molecular motor Myo1D as a chiral determinant that is sufficient to break symmetry at all biological scales through chiral interaction with the actin cytoskeleton.
Title: Molecular to organismal chirality is induced by the conserved myosin 1D.
Myo31DF-overexpressing cells suggest that cell-shape chirality was established in each cell and reflects intrinsic planar cell chirality.
Title: Left-right asymmetry is formed in individual cells by intrinsic cell chirality.
DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
Title: DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
left-right(LR)directional rotation of hindgut epithelial tube; DECad is distributed to cell boundaries with LR asymmetry which is responsible for planar cell-shape chirality formation; myosin ID switches LR polarity found in PCC and in DE-Cad distribution
Title: Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis.
the organ specificities of the Myo31DF and Myo61F activities depended on their head regions
Title: Head region of unconventional myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila.
Myo31DF interacts and colocalizes with beta-catenin, suggesting that situs inversus genes can direct left-right development through the adherens junction
Title: Type ID unconventional myosin controls left-right asymmetry in Drosophila.
the actin cytoskeleton and myosin I proteins may be crucial for generating left-right asymmetry in invertebrates
Title: An unconventional myosin in Drosophila reverses the default handedness in visceral organs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in hindgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin 31DF

Names: CG7438-PA; CG7438-PB; CG7438-PC; Myo31DF-PA; Myo31DF-PB; Myo31DF-PC; Myosin31DF; myosin 1D; myosin 1a; myosin I; myosin IA; myosin ID; myosin-IA; myosin1A; souther; type ID unconventional myosin 31DF; unconventional myosin 31DF

NP_001188784.1

EC 5.6.1.8

NP_523538.1

EC 5.6.1.8

NP_723596.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10491814..10506779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078814.4 → NP_523538.1 myosin 31DF, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523538.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0K5, M9MRS7, Q23978

Related

FBpp0079625

Conserved Domains (3) summary

smart00242
Location:6 → 690

MYSc; Myosin. Large ATPases

cd01378
Location:21 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:801 → 983

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001201855.2 → NP_001188784.1 myosin 31DF, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188784.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0K5, M9MRS7, Q23978

Conserved Domains (3) summary

smart00242
Location:6 → 690

MYSc; Myosin. Large ATPases

cd01378
Location:21 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:801 → 983

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_164933.3 → NP_723596.1 myosin 31DF, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0K5, M9MRS7, Q23978

Related

FBpp0079626

Conserved Domains (3) summary

smart00242
Location:6 → 690

MYSc; Myosin. Large ATPases

cd01378
Location:21 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:801 → 983

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding