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    Ptpn18 protein tyrosine phosphatase, non-receptor type 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301333, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ptpn18provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 18provided by RGD
    Primary source
    RGD:1311586
    See related
    Ensembl:ENSRNOG00000013415 AllianceGenome:RGD:1311586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PTP20
    Summary
    Predicted to enable non-membrane spanning protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within blastocyst formation. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPN18 (protein tyrosine phosphatase non-receptor type 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 227.2), Thymus (RPKM 176.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn18 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44166571..44185885)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36672325..36689963)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (40972089..40988790)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094660 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 5 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene uncharacterized LOC134480354 Neighboring gene protease, serine, 39 Neighboring gene cripto, FRL-1, cryptic family 1 Neighboring gene small nucleolar RNA, H/ACA box 51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Wang HM, et al. Cell Res, 2014 Sep. PMID 25081058, Free PMC Article
    2. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Huang K, et al. Oncogene, 1996 Oct 3. PMID 8875997
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112761, MGC112828

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 18
    Names
    protein tyrosine phosphatase 20
    NP_001013129.2
    XP_038939136.1
    XP_038939138.1
    XP_038939139.1
    XP_038939141.1
    XP_038939142.1
    XP_038939143.1
    XP_038939145.1
    XP_063122948.1
    XP_063122949.1
    XP_063122950.1
    XP_063122951.1
    XP_063122952.1
    XP_063122953.1
    XP_063122954.1
    XP_063122955.1
    XP_063122956.1
    XP_063122957.1
    XP_063122958.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013111.2 → NP_001013129.2  tyrosine-protein phosphatase non-receptor type 18

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INA1, P70602
      Related
      ENSRNOP00000079548.1, ENSRNOT00000095122.1
      Conserved Domains (1) summary
      cl28904
      Location:27 → 292
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44166571..44185885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266886.1 → XP_063122956.1  tyrosine-protein phosphatase non-receptor type 18 isoform X14

    2. XM_063266878.1 → XP_063122948.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

    3. XM_063266879.1 → XP_063122949.1  tyrosine-protein phosphatase non-receptor type 18 isoform X2

    4. XM_063266880.1 → XP_063122950.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

    5. XM_039083210.2 → XP_038939138.1  tyrosine-protein phosphatase non-receptor type 18 isoform X7

      Conserved Domains (1) summary
      cl28904
      Location:27 → 298
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_063266883.1 → XP_063122953.1  tyrosine-protein phosphatase non-receptor type 18 isoform X7

    7. XM_039083215.2 → XP_038939143.1  tyrosine-protein phosphatase non-receptor type 18 isoform X12

      Conserved Domains (1) summary
      cl28904
      Location:27 → 298
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_039083214.2 → XP_038939142.1  tyrosine-protein phosphatase non-receptor type 18 isoform X11

      Conserved Domains (1) summary
      cl28904
      Location:27 → 298
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    9. XM_039083208.2 → XP_038939136.1  tyrosine-protein phosphatase non-receptor type 18 isoform X4

      UniProtKB/TrEMBL
      P70602
      Related
      ENSRNOP00000092277.1
      Conserved Domains (1) summary
      cl28904
      Location:27 → 298
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    10. XM_063266882.1 → XP_063122952.1  tyrosine-protein phosphatase non-receptor type 18 isoform X6

    11. XM_063266887.1 → XP_063122957.1  tyrosine-protein phosphatase non-receptor type 18 isoform X14

    12. XM_063266885.1 → XP_063122955.1  tyrosine-protein phosphatase non-receptor type 18 isoform X13

    13. XM_039083217.2 → XP_038939145.1  tyrosine-protein phosphatase non-receptor type 18 isoform X15

      Conserved Domains (1) summary
      cl28904
      Location:38 → 99
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    14. XM_063266881.1 → XP_063122951.1  tyrosine-protein phosphatase non-receptor type 18 isoform X5

    15. XM_063266884.1 → XP_063122954.1  tyrosine-protein phosphatase non-receptor type 18 isoform X8

    16. XM_039083211.1 → XP_038939139.1  tyrosine-protein phosphatase non-receptor type 18 isoform X9

      Conserved Domains (1) summary
      cl28904
      Location:17 → 176
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    17. XM_039083213.2 → XP_038939141.1  tyrosine-protein phosphatase non-receptor type 18 isoform X10

      Conserved Domains (1) summary
      cl28904
      Location:17 → 170
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    18. XM_063266888.1 → XP_063122958.1  tyrosine-protein phosphatase non-receptor type 18 isoform X16

      UniProtKB/TrEMBL
      Q4KM54

    RNA

    1. XR_005488868.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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