Fndc5 fibronectin type III domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fndc5provided by RGD
Official Full Name: fibronectin type III domain containing 5provided by RGD
Primary source: RGD:708525
See related: Ensembl:ENSRNOG00000030238 AllianceGenome:RGD:708525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity. Predicted to be involved in positive regulation of brown fat cell differentiation and response to muscle activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular region and plasma membrane. Orthologous to human FNDC5 (fibronectin type III domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 291.2), Muscle (RPKM 262.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (146765951..146775611)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (141481593..141491257)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (147323240..147330266)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.
Title: Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.
[Exercise promotes irisin expression to ameliorate renal injury in type 2 diabetic rats].
Title: [Exercise promotes irisin expression to ameliorate renal injury in type 2 diabetic rats].
Irisin Protects Cerebral Neurons from Hypoxia/Reoxygenation via Suppression of Apoptosis and Expression of Pro-Inflammatory Cytokines.
Title: Irisin Protects Cerebral Neurons from Hypoxia/Reoxygenation via Suppression of Apoptosis and Expression of Pro-Inflammatory Cytokines.
[Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus muscle of unloaded rats].
Title: [Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1α /FNDC5 in soleus muscle of unloaded rats].
Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions.
Title: Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions.
Irisin relaxes rat thoracic aorta through inhibiting signaling pathways implicating protein kinase C.
Title: Irisin relaxes rat thoracic aorta through inhibiting signaling pathways implicating protein kinase C.
Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5.
Title: Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5.
Long-term GABA administration improves FNDC5, TFAM, and UCP3 mRNA expressions in the skeletal muscle and serum irisin levels in chronic type 2 diabetic rats.
Title: Long-term GABA administration improves FNDC5, TFAM, and UCP3 mRNA expressions in the skeletal muscle and serum irisin levels in chronic type 2 diabetic rats.
Irisin relaxes rat thoracic aorta: MEK1/2 signaling pathway, KV channels, SKCa channels, and BKCa channels are involved in irisin-induced vasodilation.
Title: Irisin relaxes rat thoracic aorta: MEK1/2 signaling pathway, K(V) channels, SK(Ca) channels, and BK(Ca) channels are involved in irisin-induced vasodilation.
Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice.
Title: Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice.

Submit: New GeneRIF Correction See all GeneRIFs (49)

General gene information

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Markers

Fndc5 (e-PCR), detects polymorphism
- UniSTS:547982

AI836596 (e-PCR)
- UniSTS:164260

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of brown fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibronectin type III domain-containing protein 5

Names: peroxisomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270981.3 → NP_001257910.1 fibronectin type III domain-containing protein 5 precursor

See identical proteins and their annotated locations for NP_001257910.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8K3V5

Conserved Domains (2) summary

cd00063
Location:31 → 121

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:148 → 181

DUF4808; Domain of unknown function (DUF4808)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

146765951..146775611

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109329.2 → XP_038965257.1 fibronectin type III domain-containing protein 5 isoform X1

UniProtKB/TrEMBL

A0A8L2QNJ9

Related

ENSRNOP00000048830.6

Conserved Domains (2) summary

cd00063
Location:62 → 152

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam16066
Location:179 → 212

DUF4808; Domain of unknown function (DUF4808)