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    Kel Kell metallo-endopeptidase (Kell blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297025, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Kelprovided by RGD
    Official Full Name
    Kell metallo-endopeptidase (Kell blood group)provided by RGD
    Primary source
    RGD:1565470
    See related
    Ensembl:ENSRNOG00000015682 AllianceGenome:RGD:1565470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565470
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within several processes, including cellular divalent inorganic cation homeostasis; regulation of axon diameter; and skeletal muscle fiber development. Predicted to be located in membrane and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 263.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kel in Genome Data Viewer
    Location:
    4q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71534882..71552297, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70568241..70585666, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70979504..70996920, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily V, member 5 Neighboring gene LLLL and CFNLAS motif containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2, pseudogene 2 Neighboring gene olfactory receptor family 9 subfamily A member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein. Clapéron A, et al. J Biol Chem, 2005 Jun 3. PMID 15769748
    2. Giant axon formation in mice lacking Kell, XK, or Kell and XK: animal models of McLeod neuroacanthocytosis syndrome. Zhu X, et al. Am J Pathol, 2014 Mar. PMID 24405768, Free PMC Article
    3. Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Zhu X, et al. Am J Hematol, 2009 Aug. PMID 19544475
    4. The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system. Clapéron A, et al. Brain Res, 2007 May 25. PMID 17379193
    5. Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis. Rivera A, et al. Blood Cells Mol Dis, 2013 Feb. PMID 23122227, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate the lack of Kell expression in rodent neuronal cells. Kell expression is restricted to red blood cells in cerebral vessels.
      Title: The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of axon diameter ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kell blood group glycoprotein
    Names
    Kell blood group, metallo-endopeptidase
    NP_001178540.1
    XP_006236439.1
    XP_063141823.1
    XP_063141824.1
    XP_063141825.1
    XP_063141826.1
    XP_063141827.1
    XP_063141828.1
    XP_063141829.1
    XP_063141830.1
    XP_063141831.1
    XP_063141832.1
    XP_063141833.1
    XP_063141834.1
    XP_063141835.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191611.1 → NP_001178540.1  kell blood group glycoprotein

      See identical proteins and their annotated locations for NP_001178540.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      F1M761
      Conserved Domains (2) summary
      cd08662
      Location:78 → 711
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:75 → 713
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      71534882..71552297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285761.1 → XP_063141831.1  kell blood group glycoprotein isoform X8

    2. XM_063285756.1 → XP_063141826.1  kell blood group glycoprotein isoform X3

    3. XM_063285759.1 → XP_063141829.1  kell blood group glycoprotein isoform X6

    4. XM_063285757.1 → XP_063141827.1  kell blood group glycoprotein isoform X4

    5. XM_006236377.5 → XP_006236439.1  kell blood group glycoprotein isoform X1

      See identical proteins and their annotated locations for XP_006236439.1

      UniProtKB/TrEMBL
      F1M761
      Related
      ENSRNOP00000021486.5
      Conserved Domains (2) summary
      cd08662
      Location:78 → 711
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:75 → 713
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    6. XM_063285754.1 → XP_063141824.1  kell blood group glycoprotein isoform X2

    7. XM_063285753.1 → XP_063141823.1  kell blood group glycoprotein isoform X1

      UniProtKB/TrEMBL
      F1M761

    8. XM_063285758.1 → XP_063141828.1  kell blood group glycoprotein isoform X5

    9. XM_063285755.1 → XP_063141825.1  kell blood group glycoprotein isoform X2

    10. XM_063285764.1 → XP_063141834.1  kell blood group glycoprotein isoform X11

    11. XM_063285760.1 → XP_063141830.1  kell blood group glycoprotein isoform X7

    12. XM_063285762.1 → XP_063141832.1  kell blood group glycoprotein isoform X9

    13. XM_063285763.1 → XP_063141833.1  kell blood group glycoprotein isoform X10

    14. XM_063285765.1 → XP_063141835.1  kell blood group glycoprotein isoform X12

    RNA

    1. XR_010065618.1 RNA Sequence

    2. XR_010065619.1 RNA Sequence

    3. XR_010065622.1 RNA Sequence

    4. XR_010065620.1 RNA Sequence

    5. XR_010065621.1 RNA Sequence

    6. XR_010065623.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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