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    Zdhhc4 zinc finger DHHC-type palmitoyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304291, updated on 2-May-2024

    Summary

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    Official Symbol
    Zdhhc4provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 4provided by RGD
    Primary source
    RGD:1308389
    See related
    Ensembl:ENSRNOG00000051699 AllianceGenome:RGD:1308389
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 235.9), Kidney (RPKM 72.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc4 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16344447..16358493)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11230864..11244898)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13284508..13298519)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene Grid2 interacting protein Neighboring gene uncharacterized LOC134481326 Neighboring gene integrator complex subunit 15 Neighboring gene uncharacterized LOC108352423 Neighboring gene zinc finger protein 853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Gorleku OA, et al. J Biol Chem, 2011 Nov 11. PMID 21926431, Free PMC Article
    2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108810

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC4
    Names
    DHHC-4
    membrane-associated DHHC4 zinc finger protein
    probable palmitoyltransferase ZDHHC4
    zinc finger DHHC domain-containing protein 4
    zinc finger, DHHC domain containing 4
    zinc finger, DHHC-type containing 4
    NP_001013141.1
    XP_006248938.1
    XP_038945287.1
    XP_038945290.1
    XP_063127328.1
    XP_063127329.1
    XP_063127330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013123.1 → NP_001013141.1  palmitoyltransferase ZDHHC4

      See identical proteins and their annotated locations for NP_001013141.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089831
      UniProtKB/Swiss-Prot
      Q2TGK2, Q5FVR1
      UniProtKB/TrEMBL
      F1LQN6
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16344447..16358493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271260.1 → XP_063127330.1  palmitoyltransferase ZDHHC4 isoform X3

    2. XM_063271258.1 → XP_063127328.1  palmitoyltransferase ZDHHC4 isoform X1

    3. XM_006248876.5 → XP_006248938.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_006248938.1

      UniProtKB/TrEMBL
      F1LQN6
      Related
      ENSRNOP00000073588.2
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    4. XM_039089362.2 → XP_038945290.1  palmitoyltransferase ZDHHC4 isoform X2

      UniProtKB/TrEMBL
      A6K1L5
      Conserved Domains (1) summary
      pfam01529
      Location:8 → 149
      DHHC; DHHC palmitoyltransferase

    5. XM_039089359.2 → XP_038945287.1  palmitoyltransferase ZDHHC4 isoform X2

      UniProtKB/TrEMBL
      A6K1L5
      Conserved Domains (1) summary
      pfam01529
      Location:8 → 149
      DHHC; DHHC palmitoyltransferase

    6. XM_063271259.1 → XP_063127329.1  palmitoyltransferase ZDHHC4 isoform X2

      UniProtKB/TrEMBL
      A6K1L5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVR1.1 GenPept UniProtKB/Swiss-Prot:Q5FVR1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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