Dlgap3 DLG associated protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlgap3provided by RGD
Official Full Name: DLG associated protein 3provided by RGD
Primary source: RGD:708349
See related: Ensembl:ENSRNOG00000014302 AllianceGenome:RGD:708349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dap3; DAP-3; SAPAP3
Summary: Enables PDZ domain binding activity; molecular adaptor activity; and scaffold protein binding activity. Involved in protein-containing complex assembly. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Orthologous to human DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 101.8), Thymus (RPKM 7.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (144776414..144847097)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (139491972..139562625)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (145234757..145304536)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alternative translation initiation events appear to regulate relative expression of distinct SAPAP3 isoforms in different brain regions, which may function to influence synaptic plasticity.
Title: Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation.
During the first postnatal week,PSD-95 immunoreactive strongly concentrated in the Purkinje cell layer.By P14, PSD-95 localized to many small puncta in the ML and to large clusters at mossy fiber rosettes in the glomerular layer.
Title: Localization of synapsin-I and PSD-95 in developing postnatal rat cerebellar cortex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
involved_in modification of synaptic structure	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cholinergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disks large-associated protein 3

Names: PSD-95/SAP90-associated protein-3; PSD-95/SAP90-binding protein 3; SAP90/PSD-95-associated protein 3; discs large homolog associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276304.1 → NP_001263233.1 disks large-associated protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1. The 5' UTR and 5' coding region for variant 2 are identical to those of variant 1 so the synthesis of two isoforms based on alternate in-frame translation starts discussed in PMID: 227619920 for variant 1 may also occur.

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P97838, Q6QQA8, Q6QQA9

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 966

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_001301876.3 → NP_001288805.1 disks large-associated protein 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript which can encode two isoforms based on alternate in-frame translation starts (PMID: 227619920). The shorter isoform (3, also known as beta) represented in this RefSeq is translated from the downstream AUG start codon.

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P97838, Q6QQA8, Q6QQA9

Conserved Domains (1) summary

pfam03359
Location:534 → 885

GKAP; Guanylate-kinase-associated protein (GKAP) protein
NM_173138.6 → NP_775161.2 disks large-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_775161.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript which can encode two isoforms based on alternate in-frame translation starts (PMID: 227619920). The longer isoform (1, also known as alpha) represented in this RefSeq is translated from the upstream AUG start codon.

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P97838, Q6QQA8, Q6QQA9

UniProtKB/TrEMBL

A6ISC6, G3V7T8

Related

ENSRNOP00000019214.4, ENSRNOT00000019214.5

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

144776414..144847097

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109349.2 → XP_038965277.1 disks large-associated protein 3 isoform X1

UniProtKB/Swiss-Prot

P97838, Q6QQA8, Q6QQA9

UniProtKB/TrEMBL

A6ISC6, G3V7T8

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_063287225.1 → XP_063143295.1 disks large-associated protein 3 isoform X2
XM_008763989.4 → XP_008762211.1 disks large-associated protein 3 isoform X1

See identical proteins and their annotated locations for XP_008762211.1

UniProtKB/Swiss-Prot

P97838, Q6QQA8, Q6QQA9

UniProtKB/TrEMBL

A6ISC6, G3V7T8

Conserved Domains (2) summary

PHA03418
Location:515 → 607

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:626 → 977

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_039109350.2 → XP_038965278.1 disks large-associated protein 3 isoform X3

Conserved Domains (2) summary

PHA03418
Location:58 → 150

PHA03418; hypothetical E4 protein; Provisional

pfam03359
Location:169 → 520

GKAP; Guanylate-kinase-associated protein (GKAP) protein