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    Cyth3 cytohesin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116693, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Cyth3provided by RGD
    Official Full Name
    cytohesin 3provided by RGD
    Primary source
    RGD:620399
    See related
    Ensembl:ENSRNOG00000001065 AllianceGenome:RGD:620399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sec7; Pscd3; Sec7C
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in Golgi vesicle transport. Predicted to act upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Predicted to be located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human CYTH3 (cytohesin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 457.5), Lung (RPKM 456.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyth3 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15953781..16076584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10840137..10933792, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12877559..12907771, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481266 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene Rac family small GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Malaby AW, et al. Proc Natl Acad Sci U S A, 2013 Aug 27. PMID 23940353, Free PMC Article
    2. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. Venkateswarlu K, et al. Biochem J, 1998 Oct 1. PMID 9742223, Free PMC Article
    3. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. Franco M, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707577, Free PMC Article
    4. Rat homologues of yeast sec7p. Telemenakis I, et al. Eur J Cell Biol, 1997 Oct. PMID 9352219
    5. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Klarlund JK, et al. Science, 1997 Mar 28. PMID 9072969

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124579

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of epithelial cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytohesin-3
    Names
    PH, SEC7 and coiled-coil domain-containing protein 3
    SEC7 homolog C
    pleckstrin homology, Sec7 and coiled/coil domains 3
    rSec7-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053912.2 → NP_446364.2  cytohesin-3

      See identical proteins and their annotated locations for NP_446364.2

      Status: PROVISIONAL

      Source sequence(s)
      BC101884
      UniProtKB/Swiss-Prot
      P97696
      UniProtKB/TrEMBL
      Q3T1J6
      Related
      ENSRNOP00000001412.8, ENSRNOT00000001412.8
      Conserved Domains (2) summary
      cd01252
      Location:263 → 382
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:66 → 248
      Sec7; Sec7 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15953781..16076584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271013.1 → XP_063127083.1  cytohesin-3 isoform X3

      UniProtKB/TrEMBL
      A6K1K3

    2. XM_063271012.1 → XP_063127082.1  cytohesin-3 isoform X2

    3. XM_039089028.2 → XP_038944956.1  cytohesin-3 isoform X3

      UniProtKB/Swiss-Prot
      P97696
      UniProtKB/TrEMBL
      A6K1K3
      Conserved Domains (2) summary
      cd01252
      Location:215 → 334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18 → 200
      Sec7; Sec7 domain

    4. XM_039089024.2 → XP_038944952.1  cytohesin-3 isoform X1

      UniProtKB/Swiss-Prot
      P97696
      Conserved Domains (2) summary
      cd01252
      Location:335 → 454
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:138 → 320
      Sec7; Sec7 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97696.1 GenPept UniProtKB/Swiss-Prot:P97696

    Gene LinkOut

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