Gstk1 glutathione S-transferase kappa 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gstk1provided by RGD
Official Full Name: glutathione S-transferase kappa 1provided by RGD
Primary source: RGD:735188
See related: Ensembl:ENSRNOG00000016484 AllianceGenome:RGD:735188
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GST13-13; GSTkappa
Summary: Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be involved in epithelial cell differentiation and glutathione metabolic process. Located in mitochondrial matrix. Orthologous to human GSTK1 (glutathione S-transferase kappa 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 566.4), Kidney (RPKM 206.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (72085532..72089934)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (71118979..71123298)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (71621777..71626096)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase kappa 1

Names: GST 13-13; GST class-kappa; GSTK1-1; glutathione S-transferase subunit 13; glutathione S-transferase, mitochondrial; rGSTK1

NP_852036.1

EC 2.5.1.18

XP_063141836.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181371.2 → NP_852036.1 glutathione S-transferase kappa 1

See identical proteins and their annotated locations for NP_852036.1

Status: PROVISIONAL

Source sequence(s)

S83436

UniProtKB/Swiss-Prot

O09034, P24473

UniProtKB/TrEMBL

B6DYQ0

Related

ENSRNOP00000022275.2, ENSRNOT00000022275.5

Conserved Domains (1) summary

cd03021
Location:6 → 211

DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...