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    Zfp788 zinc finger protein 788 [ Mus musculus (house mouse) ]

    Gene ID: 67607, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp788provided by MGI
    Official Full Name
    zinc finger protein 788provided by MGI
    Primary source
    MGI:MGI:1914857
    See related
    Ensembl:ENSMUSG00000074165 AllianceGenome:MGI:1914857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810426N06Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 4.9), CNS E14 (RPKM 4.3) and 17 other tissues See more
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    Genomic context

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    Location:
    7 B3; 7 28.25 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (41282955..41300305)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (41633531..41650881)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6871 Neighboring gene STARR-seq mESC enhancer starr_18730 Neighboring gene STARR-seq mESC enhancer starr_18731 Neighboring gene STARR-seq mESC enhancer starr_18732 Neighboring gene STARR-positive B cell enhancer ABC_E3716 Neighboring gene predicted gene, 51480 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:48888363-48888572 Neighboring gene vomeronasal 2, receptor, pseudogene 54 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene CTD nuclear envelope phosphatase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    2. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Hassel S, et al. Proteomics, 2004 May. PMID 15188402
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 788

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360674.1 → NP_001347603.1  zinc finger protein 788 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS90214.1
      UniProtKB/TrEMBL
      E9Q980
      Conserved Domains (4) summary
      COG5048
      Location:488 → 883
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 64
      KRAB; KRAB box
      pfam13465
      Location:308 → 332
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001360675.1 → NP_001347604.1  zinc finger protein 788 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS90214.1
      UniProtKB/TrEMBL
      E9Q980
      Related
      ENSMUSP00000096108.3, ENSMUST00000098508.9
      Conserved Domains (4) summary
      COG5048
      Location:488 → 883
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 64
      KRAB; KRAB box
      pfam13465
      Location:308 → 332
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001360677.1 → NP_001347606.1  zinc finger protein 788 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI605193, AK020228, AK163311, CD544822
      Conserved Domains (4) summary
      COG5048
      Location:473 → 868
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 49
      KRAB; KRAB box
      pfam13465
      Location:293 → 317
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001360678.1 → NP_001347607.1  zinc finger protein 788 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS90213.1
      UniProtKB/TrEMBL
      E9PZ68
      Related
      ENSMUSP00000035499.8, ENSMUST00000045720.14
      Conserved Domains (4) summary
      COG5048
      Location:468 → 863
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:416 → 436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box
      pfam13465
      Location:288 → 312
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001360680.1 → NP_001347609.1  zinc finger protein 788 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5-9 all encode the same isoform (d).
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS39922.1
      UniProtKB/TrEMBL
      Q6PIW5, Q8BUQ3
      Conserved Domains (3) summary
      COG5048
      Location:436 → 831
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 280
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001360681.1 → NP_001347610.1  zinc finger protein 788 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5-9 all encode the same isoform (d).
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS39922.1
      UniProtKB/TrEMBL
      Q6PIW5, Q8BUQ3
      Related
      ENSMUSP00000132848.2, ENSMUST00000170770.2
      Conserved Domains (3) summary
      COG5048
      Location:436 → 831
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 280
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001360683.1 → NP_001347612.1  zinc finger protein 788 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5-9 all encode the same isoform (d).
      Source sequence(s)
      AI605193, AK020228, AK163311, CD544822
      Consensus CDS
      CCDS39922.1
      UniProtKB/TrEMBL
      Q6PIW5, Q8BUQ3
      Conserved Domains (3) summary
      COG5048
      Location:436 → 831
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 280
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001360684.1 → NP_001347613.1  zinc finger protein 788 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5-9 all encode the same isoform (d).
      Source sequence(s)
      AC108827
      Consensus CDS
      CCDS39922.1
      UniProtKB/TrEMBL
      Q6PIW5, Q8BUQ3
      Conserved Domains (3) summary
      COG5048
      Location:436 → 831
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 280
      zf-H2C2_2; Zinc-finger double domain

    9. NM_023363.3 → NP_075852.1  zinc finger protein 788 isoform d

      See identical proteins and their annotated locations for NP_075852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5-9 all encode the same isoform (d).
      Source sequence(s)
      AC108827, AI605193, AK082981
      Consensus CDS
      CCDS39922.1
      UniProtKB/TrEMBL
      Q6PIW5, Q8BUQ3
      Related
      ENSMUSP00000097847.4, ENSMUST00000100275.10
      Conserved Domains (3) summary
      COG5048
      Location:436 → 831
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:256 → 280
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      41282955..41300305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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