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    Zswim5 zinc finger SWIM-type containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 74464, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zswim5provided by MGI
    Official Full Name
    zinc finger SWIM-type containing 5provided by MGI
    Primary source
    MGI:MGI:1921714
    See related
    Ensembl:ENSMUSG00000033948 AllianceGenome:MGI:1921714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1511; 4933426E21Rik
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in eye; male reproductive gland or organ; metanephros; small intestine; and telencephalon. Orthologous to human ZSWIM5 (zinc finger SWIM-type containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 8.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.37 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116731326..116846461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116877402..116989105)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11251 Neighboring gene predicted gene 12996 Neighboring gene ribosomal protein L36, pseudogene 8 Neighboring gene predicted gene, 22092 Neighboring gene general transcription factor IIB pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116666946-116667171 Neighboring gene uroporphyrinogen decarboxylase Neighboring gene HECT domain E3 ubiquitin protein ligase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain. Chang CC, et al. J Comp Neurol, 2020 Oct. PMID 32144752
    2. Temporal and regulatory dynamics of the inner ear transcriptome during development in mice. Cao R, et al. Sci Rep, 2022 Dec 7. PMID 36476755, Free PMC Article
    3. Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. Tucker ES, et al. J Neurosci, 2008 Sep 17. PMID 18799682, Free PMC Article
    4. Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Tischfield DJ, et al. Neurobiol Dis, 2017 Jul. PMID 28433741, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain.
      Title: Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029912.3 → NP_001025083.1  zinc finger SWIM domain-containing protein 5

      See identical proteins and their annotated locations for NP_001025083.1

      Status: VALIDATED

      Source sequence(s)
      AL671671, AL683847
      Consensus CDS
      CCDS18520.1
      UniProtKB/Swiss-Prot
      Q80TC6
      Related
      ENSMUSP00000049474.4, ENSMUST00000044823.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116731326..116846461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164501.1 → XP_036020394.1  zinc finger SWIM domain-containing protein 5 isoform X1

      Conserved Domains (1) summary
      PHA03247
      Location:2 → 104
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TC6.2 GenPept UniProtKB/Swiss-Prot:Q80TC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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