Slc30a1 solute carrier family 30 (zinc transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a1provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 1provided by MGI
Primary source: MGI:MGI:1345281
See related: Ensembl:ENSMUSG00000037434 AllianceGenome:MGI:1345281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znt1; C130040I11Rik
Summary: Enables calcium channel inhibitor activity. Involved in cellular divalent inorganic cation homeostasis; negative regulation of ion transport; and zinc ion transport. Acts upstream of or within in utero embryonic development. Predicted to be located in T-tubule; cytoplasm; and nuclear membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and nose. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 14.4), colon adult (RPKM 12.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (191638810..191645359)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191906697..191913248)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study has identified ZnT1 as a novel postsynaptic density protein.
Title: Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses.
C-terminal domain of ZnT-1 was responsible for its protective effect against ischemia-reperfusion , while this part of the ZnT-1 protein did not have a protective effect against the toxicity of zinc
Title: ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling.
Data suggest that expression of zinc homeostatic proteins such as ZnT1 and 3, and metallothioneins 1 and 2, is regulated by crosstalk between synaptic and intracellular pools of Zn(2+).
Title: Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc.
The expression of Slc30a1, Slc39a8, and Slc39a10 in the erythrocytes of zinc deficient and replete mice is reported.
Title: Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency.
Cadmium exposure down-regulated ZnT-1 gene expression in the conceptus of mice.
Title: Expression of ZnT-1 (Slc30a1) and MT-1 (Mt1) in the conceptus of cadmium treated mice.
Expression of zinc transporter ZnT1 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Title: Dynamic zinc pools in mouse choroid plexus.
Znt1 provides an essential function during early embryonic development.
Title: Mouse zinc transporter 1 gene provides an essential function during early embryonic development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a1 (e-PCR), detects polymorphism
- UniSTS:547331

AI029423 (e-PCR)
- UniSTS:246020

AI839647 (e-PCR)
- UniSTS:165136

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in detoxification of cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in detoxification of zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of zinc ion transmembrane import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within zinc ion transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in glutamatergic postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A1

Names: solute carrier family 30 member 1; zinc transporter 1; znT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009579.3 → NP_033605.1 proton-coupled zinc antiporter SLC30A1

See identical proteins and their annotated locations for NP_033605.1

Status: VALIDATED

Source sequence(s)

AC114603, BC052166, CX217007

Consensus CDS

CCDS15625.1

UniProtKB/Swiss-Prot

Q60738

UniProtKB/TrEMBL

Q3UM63

Related

ENSMUSP00000042410.7, ENSMUST00000044954.7

Conserved Domains (2) summary

COG1230
Location:6 → 418

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:21 → 339

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

191638810..191645359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497158.5 → XP_006497221.1 proton-coupled zinc antiporter SLC30A1 isoform X1

Conserved Domains (1) summary

COG1230
Location:6 → 140

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]