NLGN1 neuroligin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NLGN1provided by HGNC
Official Full Name: neuroligin 1provided by HGNC
Primary source: HGNC:HGNC:14291
See related: Ensembl:ENSG00000169760 MIM:600568; AllianceGenome:HGNC:14291
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NL1; NLG1
Summary: This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 1.7), testis (RPKM 0.4) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q26.31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (173395952..174294372)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (176181719..177081314)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (173113742..174012162)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder.
Title: Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder.
The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/beta-catenin pathway.
Title: The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.
Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.
Title: Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.
Title: Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.
Upregulated NLGN1 predicts poor survival in colorectal cancer.
Title: Upregulated NLGN1 predicts poor survival in colorectal cancer.
Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Title: Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
Title: TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
we propose that this homozygous variant in NLGN1 can be the cause of the ASD/ID of these brothers although functional studies and/or model systems will be necessary to provide evidence for its pathogenicity.
Title: A novel nonsense homozygous variant in the NLGN1 gene found in a pair of monozygotic twin brothers with intellectual disability and autism.
Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD.
Title: Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD
Title: Functional significance of rare neuroligin 1 variants found in autism.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autism, susceptibility to, 20 MedGen: C5394226 OMIM: 618830 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2016-03-25) ClinGen Genome Curation Page Haploinsufficency No evidence available (Last evaluated 2016-03-25) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of major recurrent depression in the U.K. population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G31504 (e-PCR)
- UniSTS:38928

NLGN1__6059 (e-PCR)
- UniSTS:463637

D3S1240 (e-PCR)
- UniSTS:147223

G65623 (e-PCR)
- UniSTS:225559

RH104007 (e-PCR)
- UniSTS:98332

RH47794 (e-PCR)
- UniSTS:79144

SHGC-77554 (e-PCR)
- UniSTS:79926

SHGC-105283 (e-PCR)
- UniSTS:169272

RH46211 (e-PCR)
- UniSTS:72004

RH123586 (e-PCR)
- UniSTS:136006

RH120987 (e-PCR)
- UniSTS:133746

D3S1565 (e-PCR), detects polymorphism
- UniSTS:37496

SHGC-24334 (e-PCR)
- UniSTS:10119

RH120677 (e-PCR)
- UniSTS:132758

RH48275 (e-PCR)
- UniSTS:83104

RH119354 (e-PCR)
- UniSTS:138921

RH48016 (e-PCR)
- UniSTS:81585

SHGC-84720 (e-PCR)
- UniSTS:104115

D3S1565 (e-PCR), detects polymorphism
- UniSTS:63165

D3S2425 (e-PCR), detects polymorphism
- UniSTS:82628

RH122102 (e-PCR)
- UniSTS:134854

SHGC-111576 (e-PCR)
- UniSTS:168407

SHGC-105188 (e-PCR)
- UniSTS:169198

WI-11234 (e-PCR)
- UniSTS:54519

D3S2361 (e-PCR)
- UniSTS:77053

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	NAS Non-traceable Author Statement more info	PubMed
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurexin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables neurexin family protein binding	NAS Non-traceable Author Statement more info	PubMed
enables scaffold protein binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in NMDA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion involved in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeletal matrix organization at active zone	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of synapse structure	NAS Non-traceable Author Statement more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendritic spine morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurexin clustering involved in presynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in neuron cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in neuronal signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuromuscular synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of neuron projection development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glutamatergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic density protein 95 clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of NMDA receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle targeting	ISS Inferred from Sequence or Structural Similarity more info
involved_in terminal button organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in asymmetric, glutamatergic, excitatory synapse	TAS Traceable Author Statement more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in filopodium tip	ISS Inferred from Sequence or Structural Similarity more info
located_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in inhibitory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in neuromuscular junction	NAS Non-traceable Author Statement more info	PubMed
located_in neuron to neuron synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
located_in postsynaptic density	TAS Traceable Author Statement more info	PubMed
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell-cell adhesion	EXP Inferred from Experiment more info	PubMed
part_of protein complex involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuroligin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046919.2 RefSeqGene

Range

6846..903474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001365923.2 → NP_001352852.1 neuroligin-1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365924.2 → NP_001352853.1 neuroligin-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS93427.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

UniProtKB/TrEMBL

A0A8Q3SHM6

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365925.2 → NP_001352854.1 neuroligin-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS93427.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

UniProtKB/TrEMBL

A0A8Q3SHM6

Related

ENSP00000511841.1, ENST00000695368.1

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365926.2 → NP_001352855.1 neuroligin-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS93427.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

UniProtKB/TrEMBL

A0A8Q3SHM6

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365927.2 → NP_001352856.1 neuroligin-1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC092923, AC092967

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Related

ENSP00000410374.2, ENST00000415045.2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365928.2 → NP_001352857.1 neuroligin-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC092923, AC092967

Consensus CDS

CCDS93427.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

UniProtKB/TrEMBL

A0A8Q3SHM6

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
NM_001365929.2 → NP_001352858.1 neuroligin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
NM_001365930.2 → NP_001352859.1 neuroligin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
NM_001365931.2 → NP_001352860.1 neuroligin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
NM_001365932.2 → NP_001352861.1 neuroligin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
NM_001365933.2 → NP_001352862.1 neuroligin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC092923, AC092967

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Related

ENSP00000354541.4, ENST00000361589.8

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
NM_001365934.2 → NP_001352863.1 neuroligin-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC092923, AC092967

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 597

COesterase; Carboxylesterase family
NM_001365935.2 → NP_001352864.1 neuroligin-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 597

COesterase; Carboxylesterase family
NM_001365936.2 → NP_001352865.1 neuroligin-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, AC092923, AC092967

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 597

COesterase; Carboxylesterase family
NM_014932.5 → NP_055747.1 neuroligin-1 isoform 3 precursor

See identical proteins and their annotated locations for NP_055747.1

Status: REVIEWED

Source sequence(s)

AC008120, AC018456, BC032555, DA310134

Consensus CDS

CCDS3222.1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Related

ENSP00000392500.1, ENST00000457714.5

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

173395952..174294372

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017005893.2 → XP_016861382.1 neuroligin-1 isoform X1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
XM_047447706.1 → XP_047303662.1 neuroligin-1 isoform X2
XM_017005896.2 → XP_016861385.1 neuroligin-1 isoform X1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
XM_047447712.1 → XP_047303668.1 neuroligin-1 isoform X5
XM_017005888.2 → XP_016861377.1 neuroligin-1 isoform X1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
XM_047447709.1 → XP_047303665.1 neuroligin-1 isoform X5
XM_047447708.1 → XP_047303664.1 neuroligin-1 isoform X4
XM_017005902.2 → XP_016861391.1 neuroligin-1 isoform X5

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 597

COesterase; Carboxylesterase family
XM_047447707.1 → XP_047303663.1 neuroligin-1 isoform X3
XM_047447702.1 → XP_047303658.1 neuroligin-1 isoform X1
XM_017005900.2 → XP_016861389.1 neuroligin-1 isoform X4

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 606

COesterase; Carboxylesterase family
XM_047447710.1 → XP_047303666.1 neuroligin-1 isoform X5
XM_047447704.1 → XP_047303660.1 neuroligin-1 isoform X3
XM_047447701.1 → XP_047303657.1 neuroligin-1 isoform X1
XM_047447703.1 → XP_047303659.1 neuroligin-1 isoform X2
XM_017005895.3 → XP_016861384.1 neuroligin-1 isoform X1

UniProtKB/Swiss-Prot

D2X2H5, Q8N2Q7, Q9UPT2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
XM_047447705.1 → XP_047303661.1 neuroligin-1 isoform X2
XM_005247237.4 → XP_005247294.1 neuroligin-1 isoform X6

Conserved Domains (2) summary

COG0657
Location:14 → 112

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:16 → 454

COesterase; Carboxylesterase family
XM_047447713.1 → XP_047303669.1 neuroligin-1 isoform X7
XM_047447714.1 → XP_047303670.1 neuroligin-1 isoform X7
XM_011512553.3 → XP_011510855.1 neuroligin-1 isoform X7

See identical proteins and their annotated locations for XP_011510855.1

Conserved Domains (1) summary

cl21494
Location:2 → 292

Abhydrolase; alpha/beta hydrolases