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    Exoc6 exocyst complex component 6 [ Mus musculus (house mouse) ]

    Gene ID: 107371, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Exoc6provided by MGI
    Official Full Name
    exocyst complex component 6provided by MGI
    Primary source
    MGI:MGI:1351611
    See related
    Ensembl:ENSMUSG00000053799 AllianceGenome:MGI:1351611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hbd; Sec15; msec15; Sec15l1; C430002C19; 4833405E05Rik
    Summary
    Acts upstream of or within erythrocyte differentiation. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in central nervous system; dorsal root ganglion; foregut; genitourinary system; and liver lobe. Orthologous to human EXOC6 (exocyst complex component 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.6), liver E14 (RPKM 11.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exoc6 in Genome Data Viewer
    Location:
    19 C2; 19 32.32 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37525181..37672499)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37536763..37684052)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122C19 gene Neighboring gene predicted gene, 32294 Neighboring gene predicted gene, 41842 Neighboring gene STARR-seq mESC enhancer starr_46060 Neighboring gene STARR-seq mESC enhancer starr_46061 Neighboring gene STARR-seq mESC enhancer starr_46062 Neighboring gene predicted gene, 32342 Neighboring gene cytochrome P450, family 26, subfamily c, polypeptide 1 Neighboring gene cytochrome P450, family 26, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling. Zhang AS, et al. Exp Hematol, 2006 May. PMID 16647565
    2. B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit mice. Lipovsky K, et al. Exp Hematol, 2003 Dec. PMID 14662329
    3. The hemoglobin-deficit mouse: cure of the anemia following bone marrow transplantation with normal marrow. Simon-Stoos KL, et al. Exp Hematol, 1999 Jan. PMID 9923455
    4. The hemoglobin-deficit mouse: analysis of phenotype and hematopoiesis in the transplant model. Bloom ML, et al. Blood, 1997 Sep 1. PMID 9292544
    5. [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Scheufler H. Z Versuchstierkd, 1969. PMID 5405927

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the association of Rab10-GTP with Exoc6/6b is a molecular link between insulin signaling and the exocytic machinery in GLUT4 translocation.
      Title: A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b.
    2. Exoc3l is involved in regulated exocytosis of insulin granules; expressed in insulin-secreting cells as well as in various tissues including pancreatic islets and brain.
      Title: Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion.
    3. These data indicate that rapid transferrin recycling is defective after pSec15l1 has mutated.
      Title: Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice.
    4. Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
      Title: Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking.
    5. Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
      Title: A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    hemoglobin deficient
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 6
    Names
    SEC15 homolog
    SEC15-like 1
    SEC15-like protein 1
    exocyst complex component Sec15A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175353.2 → NP_780562.2  exocyst complex component 6

      See identical proteins and their annotated locations for NP_780562.2

      Status: VALIDATED

      Source sequence(s)
      AC110212, AK076455, AK082881, BY100185, CD806857
      Consensus CDS
      CCDS29779.1
      UniProtKB/TrEMBL
      A0A5F8MPW8, Q3U9D6
      Related
      ENSMUSP00000064332.7, ENSMUST00000066439.8
      Conserved Domains (1) summary
      pfam04091
      Location:456 → 762
      Sec15; Exocyst complex subunit Sec15-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      37525181..37672499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318044.2 → XP_017173533.1  exocyst complex component 6 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MP92, A0A5F8MPW8
      Related
      ENSMUSP00000158866.2, ENSMUST00000238954.2
      Conserved Domains (1) summary
      pfam04091
      Location:463 → 769
      Sec15; Exocyst complex subunit Sec15-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R313.2 GenPept UniProtKB/Swiss-Prot:Q8R313

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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