Slc25a37 solute carrier family 25, member 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a37provided by MGI
Official Full Name: solute carrier family 25, member 37provided by MGI
Primary source: MGI:MGI:1914962
See related: Ensembl:ENSMUSG00000034248 AllianceGenome:MGI:1914962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mfrn; Mscp; Mfrn1; frascati; mitoferrin; 1700020E22Rik; 4930513O14Rik; 4930526G11Rik; C330015G08Rik
Summary: Enables ferrous iron transmembrane transporter activity. Involved in iron import into the mitochondrion and positive regulation of hemoglobin biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; immune system; liver; retina nuclear layer; and yolk sac. Orthologous to human SLC25A37 (solute carrier family 25 member 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 331.9), liver E14 (RPKM 297.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.03 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (69479297..69522993, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (69241848..69285544, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
Title: The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory.
Title: Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory.
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation
Title: Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria.
total deletion of Mfrn1 in embryos leads to embryonic lethality. Selective deletion of Mfrn1 in adult hematopoietic tissues leads to severe anemia because of a deficit in erythroblast formation.
Title: Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.
The cis-regulatory modules (CRMs) that control expression of the Mfrn genes, were mapped.
Title: Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
Mitoferrin 1 can cause anemia and protoporphyria.
Title: Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.
The transcription factor GATA-1 controls expression of Mitoferrin 1 in development of mammals
Title: Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
Fech forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Title: Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.
Mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.
Title: Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.
Data show that the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1.
Title: Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mscp-pending (e-PCR), detects polymorphism
- UniSTS:234006

BB104597 (e-PCR)
- UniSTS:186008

AI848481 (e-PCR)
- UniSTS:180689

D14Mit85 (e-PCR), detects polymorphism
- UniSTS:127442

Slc25a37 (e-PCR), detects polymorphism
- UniSTS:547053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferrous iron transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in iron import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hemoglobin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitoferrin-1

Names: mitochondrial iron transporter 1; mitochondrial solute carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026331.3 → NP_080607.2 mitoferrin-1

See identical proteins and their annotated locations for NP_080607.2

Status: VALIDATED

Source sequence(s)

AF288621, AK006155, AK050414, AK162615

Consensus CDS

CCDS27238.1

UniProtKB/Swiss-Prot

Q8C367, Q8CEJ7, Q91ZY0, Q920G8, Q9D2G3, Q9D547

Related

ENSMUSP00000039990.4, ENSMUST00000037064.5

Conserved Domains (2) summary

PTZ00169
Location:44 → 307

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:44 → 136

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

69479297..69522993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519461.3 → XP_006519524.1 mitoferrin-1 isoform X1

UniProtKB/TrEMBL

Q9CQG7

Conserved Domains (1) summary

pfam00153
Location:24 → 109

Mito_carr; Mitochondrial carrier protein

RNA

XR_003950900.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_030054.2: Suppressed sequence

Description

NM_030054.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.