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    ODF4 outer dense fiber of sperm tails 4 [ Homo sapiens (human) ]

    Gene ID: 146852, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ODF4provided by HGNC
    Official Full Name
    outer dense fiber of sperm tails 4provided by HGNC
    Primary source
    HGNC:HGNC:19056
    See related
    Ensembl:ENSG00000184650 MIM:610097; AllianceGenome:HGNC:19056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT134; CT136; OPPO1
    Summary
    This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Restricted expression toward testis (RPKM 5.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See ODF4 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8339840..8346046)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8246077..8252283)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8243158..8249364)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA69 Neighboring gene uncharacterized LOC124903916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8257795-8258364 Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8279661-8280212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8285969-8286686 Neighboring gene ribosomal protein L26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and expression analysis of the testis-specific gene, human OPPO1. Miyamoto T, et al. J Assist Reprod Genet, 2004 Apr. PMID 15270212, Free PMC Article
    2. Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. Kitamura K, et al. Mol Hum Reprod, 2003 May. PMID 12728016
    3. Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient. Ghafouri-Fard S, et al. Genet Mol Res, 2012 Oct 4. PMID 23096689
    4. Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity. Ghafouri-Fard S, et al. Ann Saudi Med, 2012 May-Jun. PMID 22588436, Free PMC Article
    5. Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder. Afsharpad M, et al. Pathol Oncol Res, 2019 Jan. PMID 29058301

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High ODF4 expression is associated with Transitional Cell Carcinoma of Bladder.
      Title: Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder.
    2. Two alternative splice variants of ODF3 and ODF4, were found.
      Title: Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient.
    3. ODF4 is a cancer-testis (CT) gene useful for detection of CML. It was expressed in 30% of CML patients but not in any of the healthy donors.
      Title: Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity.
    4. Genomic structure has evolved independently of mouse, whereas functional structure is well-conserved
      Title: Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138215, MGC138219

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer dense fiber protein 4
    Names
    cancer/testis antigen 134
    cancer/testis antigen 136
    hOPPO1
    outer dense fiber 4
    outer dense fiber of sperm tails protein 4
    testis-specific protein oppo 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319953.2 → NP_001306882.1  outer dense fiber protein 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC135178
      Consensus CDS
      CCDS82069.1
      UniProtKB/TrEMBL
      C3TX97
      Related
      ENSP00000461942.1, ENST00000584943.1

    2. NM_153007.5 → NP_694552.2  outer dense fiber protein 4 isoform 1

      See identical proteins and their annotated locations for NP_694552.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB081120, AC135178
      Consensus CDS
      CCDS11140.1
      UniProtKB/Swiss-Prot
      Q2M2E3, Q8J021
      Related
      ENSP00000331086.2, ENST00000328248.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8339840..8346046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8246077..8252283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2M2E3.2 GenPept UniProtKB/Swiss-Prot:Q2M2E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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