RGS4 regulator of G protein signaling 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS4provided by HGNC
Official Full Name: regulator of G protein signaling 4provided by HGNC
Primary source: HGNC:HGNC:10000
See related: Ensembl:ENSG00000117152 MIM:602516; AllianceGenome:HGNC:10000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RGP4; SCZD9
Summary: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (163068871..163076802)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (162413422..162421357)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (163038661..163046592)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
Title: Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
Title: Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
Title: Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
RGS4 controls Galphai3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
Title: RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
Title: miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Galpha in live cells.
Title: Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells.
RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
Title: RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
Targeting RGS4 Ablates Glioblastoma Proliferation.
Title: Targeting RGS4 Ablates Glioblastoma Proliferation.
lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
Title: lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
A highly conserved delta-opioid receptor region determines RGS4 interaction.
Title: A highly conserved δ-opioid receptor region determines RGS4 interaction.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S1631 (e-PCR), detects polymorphism
- UniSTS:46361

D1S534 (e-PCR), detects polymorphism
- UniSTS:12832

HSC1YC112 (e-PCR)
- UniSTS:57391

D1S1622 (e-PCR), detects polymorphism
- UniSTS:32054

D1S3723 (e-PCR)
- UniSTS:18810

IB1262 (e-PCR)
- UniSTS:125

D1S1599 (e-PCR)
- UniSTS:68740

D1S1679 (e-PCR)
- UniSTS:48533

RGS4_784 (e-PCR)
- UniSTS:277670

D1S1656 (e-PCR), detects polymorphism
- UniSTS:58809

AA004315 (e-PCR), detects polymorphism
- UniSTS:143034

D1S196 (e-PCR), detects polymorphism
- UniSTS:53436

G29255 (e-PCR)
- UniSTS:76993

D1S1653 (e-PCR), detects polymorphism
- UniSTS:51147

SHGC-32116 (e-PCR)
- UniSTS:78034

D1S1677 (e-PCR), detects polymorphism
- UniSTS:16105

D1S551 (e-PCR), detects polymorphism
- UniSTS:38384

A003B46 (e-PCR)
- UniSTS:46321

RH12512 (e-PCR)
- UniSTS:6133

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	TAS Traceable Author Statement more info
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in dorsal root ganglion development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 4

Names: schizophrenia disorder 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023312.1 RefSeqGene

Range

5756..13197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001102445.3 → NP_001095915.1 regulator of G-protein signaling 4 isoform 1

See identical proteins and their annotated locations for NP_001095915.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL583850, DQ346664

Consensus CDS

CCDS44270.1

UniProtKB/Swiss-Prot

P49798

Related

ENSP00000397181.2, ENST00000421743.6

Conserved Domains (1) summary

cd08714
Location:160 → 273

RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
NM_001113380.1 → NP_001106851.1 regulator of G-protein signaling 4 isoform 3

See identical proteins and their annotated locations for NP_001106851.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AL583850, EF054877

Consensus CDS

CCDS44272.1

UniProtKB/Swiss-Prot

P49798

Related

ENSP00000356882.3, ENST00000367906.7

Conserved Domains (1) summary

cd08714
Location:45 → 158

RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
NM_001113381.1 → NP_001106852.1 regulator of G-protein signaling 4 isoform 4

See identical proteins and their annotated locations for NP_001106852.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AK093959, AL583850, DA660695

Consensus CDS

CCDS44271.1

UniProtKB/Swiss-Prot

P49798

Related

ENSP00000356884.4, ENST00000367908.8
NM_005613.6 → NP_005604.1 regulator of G-protein signaling 4 isoform 2

See identical proteins and their annotated locations for NP_005604.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AL583850, DQ346663

Consensus CDS

CCDS1243.1

UniProtKB/Swiss-Prot

A7XA56, A7XA58, A7XA59, A7YVV7, B1APZ3, P49798

Related

ENSP00000356885.6, ENST00000367909.11

Conserved Domains (1) summary

cd08714
Location:63 → 176

RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein