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    ARHGEF37 Rho guanine nucleotide exchange factor 37 [ Homo sapiens (human) ]

    Gene ID: 389337, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ARHGEF37provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 37provided by HGNC
    Primary source
    HGNC:HGNC:34430
    See related
    Ensembl:ENSG00000183111 MIM:620664; AllianceGenome:HGNC:34430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in skin (RPKM 21.4), prostate (RPKM 12.5) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149551625..149634968)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150086803..150169655)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148961061..149014531)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901105 Neighboring gene NANOG hESC enhancer GRCh37_chr5:148878477-148879023 Neighboring gene casein kinase 1 alpha 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82175 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82187 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:148920536-148920739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148924456-148925365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148927595-148928130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:148929064-148930263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148931159-148931952 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23378 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23379 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene MPRA-validated peak5533 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:149011522-149012721 Neighboring gene uncharacterized LOC124901104 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23384 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis. Viplav A, et al. J Cell Sci, 2019 May 8. PMID 30926623, Free PMC Article
    2. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. GENDEP Investigators, et al. Am J Psychiatry, 2013 Feb. PMID 23377640, Free PMC Article
    3. EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation. Bard-Chapeau EA, et al. Proc Natl Acad Sci U S A, 2013 Jul 30. PMID 23858473, Free PMC Article
    4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41603

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 37
    Names
    Rho guanine nucleotide exchange factor (GEF) 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001669.3 → NP_001001669.2  rho guanine nucleotide exchange factor 37

      See identical proteins and their annotated locations for NP_001001669.2

      Status: VALIDATED

      Source sequence(s)
      AC021078, AC022100, AK023814, AK123597, BC041325, BF508325, BF510234
      Consensus CDS
      CCDS43385.1
      UniProtKB/Swiss-Prot
      A1IGU5, Q6ZW51
      UniProtKB/TrEMBL
      B4DUA3
      Related
      ENSP00000328083.6, ENST00000333677.7
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606 → 662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 212
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      149551625..149634968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537642.4 → XP_011535944.1  rho guanine nucleotide exchange factor 37 isoform X3

      UniProtKB/TrEMBL
      B4DUA3
      Conserved Domains (4) summary
      cd07589
      Location:275 → 463
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:521 → 574
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:617 → 673
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:45 → 223
      RhoGEF; RhoGEF domain

    2. XM_047417170.1 → XP_047273126.1  rho guanine nucleotide exchange factor 37 isoform X4

    3. XM_006714784.4 → XP_006714847.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_006714847.1

      UniProtKB/Swiss-Prot
      A1IGU5, Q6ZW51
      UniProtKB/TrEMBL
      B4DUA3
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606 → 662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 212
      RhoGEF; RhoGEF domain

    4. XM_017009460.2 → XP_016864949.1  rho guanine nucleotide exchange factor 37 isoform X2

      UniProtKB/TrEMBL
      B4DUA3

    5. XM_005268448.2 → XP_005268505.1  rho guanine nucleotide exchange factor 37 isoform X5

      Conserved Domains (3) summary
      cd07589
      Location:50 → 238
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:296 → 349
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:392 → 448
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37

    6. XM_005268447.4 → XP_005268504.1  rho guanine nucleotide exchange factor 37 isoform X1

      See identical proteins and their annotated locations for XP_005268504.1

      UniProtKB/Swiss-Prot
      A1IGU5, Q6ZW51
      UniProtKB/TrEMBL
      B4DUA3
      Conserved Domains (4) summary
      cd07589
      Location:264 → 452
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11799
      Location:510 → 563
      SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      cd11941
      Location:606 → 662
      SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
      pfam00621
      Location:34 → 212
      RhoGEF; RhoGEF domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      150086803..150169655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352571.1 → XP_054208546.1  rho guanine nucleotide exchange factor 37 isoform X3

    2. XM_054352573.1 → XP_054208548.1  rho guanine nucleotide exchange factor 37 isoform X4

    3. XM_054352569.1 → XP_054208544.1  rho guanine nucleotide exchange factor 37 isoform X1

    4. XM_054352570.1 → XP_054208545.1  rho guanine nucleotide exchange factor 37 isoform X2

    5. XM_054352574.1 → XP_054208549.1  rho guanine nucleotide exchange factor 37 isoform X5

    6. XM_054352572.1 → XP_054208547.1  rho guanine nucleotide exchange factor 37 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1IGU5.2 GenPept UniProtKB/Swiss-Prot:A1IGU5

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