Rln1 relaxin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rln1provided by MGI
Official Full Name: relaxin 1provided by MGI
Primary source: MGI:MGI:97931
See related: Ensembl:ENSMUSG00000039097 AllianceGenome:MGI:97931
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rln; rlx
Summary: Enables signaling receptor binding activity. Involved in mammary gland development; regulation of apoptotic process; and spermatogenesis. Acts upstream of or within prostate gland growth and regulation of nitric oxide mediated signal transduction. Predicted to be located in extracellular region. Is expressed in fetal Leydig cell; ovary; and thymus. Orthologous to several human genes including RLN1 (relaxin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 1.4), CNS E14 (RPKM 0.5) and 9 other tissues See more
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Genomic context

Location:: 19 C1; 19 23.83 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29309155..29312070, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29331755..29334670, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/beta-catenin signaling pathway.
Title: Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
Title: Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
In summary, relaxin deficiency results in increased cervical collagen in late pregnancy, which is not explained by a reduction in Mmp expression or activity or decreased Rxfp1.
Title: Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity.
the data demonstrate that pregnant Rln(-/-) mice do not have the typical characteristics of preeclampsia. However, these mice show evidence of proteinuria, but we suggest that this results from systemic renal vascular dysfunction before pregnancy.
Title: Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice.
Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages.
Title: Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
SLX has roles in vascular oxidative stress, endothelial dysfunction and atherosclerotic plaque burden
Title: Anti-atherosclerotic effects of serelaxin in apolipoprotein E-deficient mice.
The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)
Title: Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.
This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient mice.
Title: Relaxin deficiency attenuates pregnancy-induced adaptation of the mesenteric artery to angiotensin II in mice.
Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging.
Title: Differential effects of relaxin deficiency on vascular aging in arteries of male mice.
we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males.
Title: A vasoactive role for endogenous relaxin in mesenteric arteries of male mice.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nipple development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prorelaxin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011272.2 → NP_035402.2 prorelaxin 1 precursor

See identical proteins and their annotated locations for NP_035402.2

Status: PROVISIONAL

Source sequence(s)

BC132656

Consensus CDS

CCDS29733.1

UniProtKB/Swiss-Prot

P47932

UniProtKB/TrEMBL

A2RTV8, Q2M2Q1

Related

ENSMUSP00000043376.5, ENSMUST00000044143.6

Conserved Domains (1) summary

cd04365
Location:145 → 183

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...