ITGA9 integrin subunit alpha 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGA9provided by HGNC
Official Full Name: integrin subunit alpha 9provided by HGNC
Primary source: HGNC:HGNC:6145
See related: Ensembl:ENSG00000144668 MIM:603963; AllianceGenome:HGNC:6145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RLC; ITGA4L; ALPHA-RLC
Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 11.9), spleen (RPKM 11.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.2

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (37452141..37823507)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (37453682..37827665)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (37493632..37864998)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells.
Title: ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells.
Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.
Title: Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population.
Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma.
Title: Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma.
ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors.
Title: ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors.
Tenascin-C regulates migration of SOX10 tendon stem cells via integrin-alpha9 for promoting patellar tendon remodeling.
Title: Tenascin-C regulates migration of SOX10 tendon stem cells via integrin-α9 for promoting patellar tendon remodeling.
Integrin-alpha9 and Its Corresponding Ligands Play Regulatory Roles in Chronic Periodontitis.
Title: Integrin-α9 and Its Corresponding Ligands Play Regulatory Roles in Chronic Periodontitis.
Integrin alpha9 is involved in the pathopoiesis of acute aortic dissection via mediating phenotype switch of vascular smooth muscle cell.
Title: Integrin α9 is involved in the pathopoiesis of acute aortic dissection via mediating phenotype switch of vascular smooth muscle cell.
miR-148a can suppress the malignant phenotype of glioblastoma by targeting ITGA9 and identify ITGA9 as a potential therapeutic target for glioblastoma.
Title: MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9.
ITGA9 level is significantly higher in triple-negative breast cancer (TNBC) than other breast cancer subtypes. Hhigher ITGA9 level is associated with significantly worse metastasis- and recurrence-free survival. Experimentally, ITGA9 KO significantly reduced TNBC cell cancer stem cell-like property, tumor angiogenesis, tumor growth and metastasis by promoting beta-catenin degradation through ILK/PKA/GSK3 pathway.
Title: Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.
This review summarises the known shared and specific roles for alpha4 and alpha9 integrins and highlights the importance of these receptors in controlling cell migration within both homeostatic and disease settings.
Title: Regulation of cell migration by α4 and α9 integrins.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of behavioral disinhibition. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G32406 (e-PCR)
- UniSTS:116993

SHGC-76831 (e-PCR)
- UniSTS:16389

D3S3452 (e-PCR)
- UniSTS:68361

SHGC-56499 (e-PCR)
- UniSTS:61974

D3S4038 (e-PCR)
- UniSTS:2587

RH16569 (e-PCR)
- UniSTS:37186

ITGA9_7239 (e-PCR)
- UniSTS:466250

RH120242 (e-PCR)
- UniSTS:132699

WI-18716 (e-PCR)
- UniSTS:59764

A009C07 (e-PCR)
- UniSTS:40063

SHGC-170004 (e-PCR)
- UniSTS:173781

SHGC-170005 (e-PCR)
- UniSTS:173782

G19873 (e-PCR)
- UniSTS:5090

A002B04 (e-PCR)
- UniSTS:5091

RH47614 (e-PCR)
- UniSTS:68078

NRU7-11A (e-PCR)
- UniSTS:12017

D3S3880 (e-PCR)
- UniSTS:64498

SHGC-173155 (e-PCR)
- UniSTS:185336

D3S3382 (e-PCR)
- UniSTS:64250

RH98242 (e-PCR)
- UniSTS:84223

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding involved in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alpha9-beta1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin alpha-9

Names: integrin alpha-RLC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.