Sgo1 shugoshin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgo1provided by MGI
Official Full Name: shugoshin 1provided by MGI
Primary source: MGI:MGI:1919665
See related: Ensembl:ENSMUSG00000023940 AllianceGenome:MGI:1919665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgol1; 3300001M08Rik
Summary: Predicted to enable kinase binding activity. Acts upstream of or within centriole-centriole cohesion. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 10.7), CNS E11.5 (RPKM 8.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 27.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (53981814..53996432, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (53674786..53691331, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-beta accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
Title: GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
The results show that shugoshin protects the centromeric synaptonemal complex in meiotic prophase and, in anaphase, promotes the proper segregation of partner chromosomes that are not linked by a crossover.
Title: Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis.
The Sgo1(-/+) mouse may serve as a novel tool for investigating mechanisms of spontaneous progression of Spontaneous late-onset Alzheimer's disease (LOAD) pathology, for early diagnosis markers, and for drug development.
Title: Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model.
MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase.
Title: SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.
Study shows Sgo1 expression in heart, gut, eye and other central nervous system tissue during development and post-development. It demonstrates Sgo1 localization in cytoplasmic region in nucleated cells in select organs.
Title: Characterization of Sgo1 expression in developing and adult mouse.
Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Title: Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
Title: Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence.
Study established the Sgo1 haploinsufficient mouse as a colon cancer model and identified antagonizing oncogenic and tumor-suppressing pathways that are differentially expressed and may be responsible for the different dynamics in the tumor development.
Title: Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model.
Sgo1(-/+)-mediated ME-CIN strongly promoted/progressed development of hepatocellular carcinoma in the presence of an initiator carcinogen, and it had a mild initiator effect by itself.
Title: Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.
Haploinsufficiency of SGO1 results in genomic instability manifested as missegregation of chromosomes and formation of extra centrosomal foci in both murine embryonic fibroblasts and adult bone marrow cells.
Title: Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centriole-centriole cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic chromosome segregation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mitotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: shugoshin 1

Names: shugoshin 1A protein; shugoshin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.