U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Treh trehalase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60576, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Trehprovided by RGD
    Official Full Name
    trehalaseprovided by RGD
    Primary source
    RGD:61831
    See related
    Ensembl:ENSRNOG00000052010 AllianceGenome:RGD:61831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha,alpha-trehalase activity. Involved in animal organ morphogenesis. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 111.6), Brain (RPKM 44.1) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    8q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53886946..53901113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44990182..45003881)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48983802..48998072)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094133 Neighboring gene DEAD-box helicase 6 Neighboring gene ribosomal protein L35A like 11 Neighboring gene uncharacterized LOC120094134 Neighboring gene pleckstrin homology-like domain, family B, member 1 Neighboring gene uncharacterized LOC134480161

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Rat trehalase: cDNA cloning and mRNA expression in adult rat tissues and during intestinal ontogeny. Oesterreicher TJ, et al. Am J Physiol, 1998 May. PMID 9644033
    2. Molecular cloning, sequencing and expression of cDNA encoding human trehalase. Ishihara R, et al. Gene, 1997 Nov 20. PMID 9427547
    3. Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage. Sasai-Takedatsu M, et al. Nephron, 1996. PMID 8773341
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    trehalase
    Names
    trehalase (brush-border membrane glycoprotein)
    NP_001129613.1
    XP_017451374.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136141.1 → NP_001129613.1  trehalase precursor

      See identical proteins and their annotated locations for NP_001129613.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J407, G3V7Q9, O70282
      Related
      ENSRNOP00000075392.1, ENSRNOT00000090203.2
      Conserved Domains (2) summary
      COG1626
      Location:16 → 551
      TreA; Neutral trehalase [Carbohydrate transport and metabolism]
      pfam01204
      Location:43 → 547
      Trehalase; Trehalase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53886946..53901113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595885.3 → XP_017451374.2  trehalase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9K4
      Related
      ENSRNOP00000088227.1
      Conserved Domains (1) summary
      cl17346
      Location:138 → 513
      Trehalase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous