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    Samd8 sterile alpha motif domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305684, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Samd8provided by RGD
    Official Full Name
    sterile alpha motif domain containing 8provided by RGD
    Primary source
    RGD:1306447
    See related
    Ensembl:ENSRNOG00000064565 AllianceGenome:RGD:1306447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Predicted to act upstream of or within ceramide phosphoethanolamine biosynthetic process. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; and integral component of plasma membrane. Orthologous to human SAMD8 (sterile alpha motif domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 243.1), Muscle (RPKM 199.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2561435..2611702, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2512104..2562368, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2685504..2731062, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482075 Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene voltage-dependent anion channel 2 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC108352868 Neighboring gene dual specificity phosphatase 13B Neighboring gene uncharacterized LOC120096899

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice. Bickert A, et al. J Lipid Res, 2015 Apr. PMID 25667419, Free PMC Article
    2. All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity. Ding T, et al. J Lipid Res, 2015 Mar. PMID 25605874, Free PMC Article
    3. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, et al. J Cell Biol, 2009 Jun 15. PMID 19506037, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide phosphoethanolamine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ceramide phosphoethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sphingomyelin synthase-related protein 1
    NP_001012040.1
    NP_001380764.1
    XP_038949161.1
    XP_063130265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012040.2 → NP_001012040.1  sphingomyelin synthase-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001012040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKT1, Q641X0
      Conserved Domains (2) summary
      cd09515
      Location:72 → 140
      SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
      pfam14360
      Location:355 → 428
      PAP2_C; PAP2 superfamily C-terminal

    2. NM_001393835.1 → NP_001380764.1  sphingomyelin synthase-related protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ARL7, A6KKT1
      Related
      ENSRNOP00000095951.1, ENSRNOT00000110077.1
      Conserved Domains (2) summary
      cd09515
      Location:26 → 94
      SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
      pfam14360
      Location:309 → 382
      PAP2_C; PAP2 superfamily C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      2561435..2611702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093233.2 → XP_038949161.1  sphingomyelin synthase-related protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KKT1
      Conserved Domains (2) summary
      cd09515
      Location:9 → 77
      SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
      pfam14360
      Location:292 → 365
      PAP2_C; PAP2 superfamily C-terminal

    2. XM_063274195.1 → XP_063130265.1  sphingomyelin synthase-related protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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