Trib2 tribbles pseudokinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trib2provided by MGI
Official Full Name: tribbles pseudokinase 2provided by MGI
Primary source: MGI:MGI:2145021
See related: Ensembl:ENSMUSG00000020601 AllianceGenome:MGI:2145021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRB2; TRB-2
Summary: Enables ubiquitin protein ligase binding activity and ubiquitin-protein transferase regulator activity. Involved in negative regulation of fat cell differentiation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and integumental system. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 34.9), whole brain E14.5 (RPKM 27.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 7.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (15841726..15866963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (15791725..15816962, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIB2 safeguards naive T cell homeostasis during aging.
Title: TRIB2 safeguards naive T cell homeostasis during aging.
TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.
Title: TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.
data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. This newly identified role indicates that Trib2 may counteract the propagation and chemotherapy resistance of leukaemia cells.
Title: A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling.
The expression profiles of TRIB1, TRIB2, and TRIB3 in human and murine hematopoietic stem, progenitor and mature cells, and in human leukemia datasets have been mapped.
Title: Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis.
results suggest that Trib2 positively promotes early erythrocyte differentiation and is essential for tolerance to hemolysis.
Title: Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice.
The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction.
Title: Anti-Tribbles Pseudokinase 2 (TRIB2)-Immunization Modulates Hypocretin/Orexin Neuronal Functions.
These data indicate that Trib2 has a complex role in the pathogenesis of Notch-driven T-ALL, which may vary between different T-ALL subtypes.
Title: Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.
TRIB1 and TRIB3 are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
Title: Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism.
we identify the contribution of dysregulated C/EBPalpha and E2F1 to elevated Trib2 expression and leukemic cell survival
Title: Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation.
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia.
Title: Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trib2 (e-PCR), detects polymorphism
- UniSTS:525617

AW319517 (e-PCR)
- UniSTS:180368

RH132990 (e-PCR)
- UniSTS:216273

Trib2 (e-PCR), detects polymorphism
- UniSTS:527584

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-binding transcription factor activity	IC Inferred by Curator more info	PubMed
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-protein transferase activity	IC Inferred by Curator more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tribbles homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422844.1 → NP_001409773.1 tribbles homolog 2

Status: VALIDATED

Source sequence(s)

AC159643

UniProtKB/Swiss-Prot

Q8K017, Q8K4K3, Q8R2V8
NM_144551.6 → NP_653134.2 tribbles homolog 2

See identical proteins and their annotated locations for NP_653134.2

Status: VALIDATED

Source sequence(s)

AC159643

Consensus CDS

CCDS25821.1

UniProtKB/Swiss-Prot

Q8K017, Q8K4K3, Q8R2V8

Related

ENSMUSP00000020922.8, ENSMUST00000020922.8

Conserved Domains (1) summary

cd14022
Location:67 → 308

PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

15841726..15866963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515055.2 → XP_006515118.1 tribbles homolog 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:45 → 273

PKc_like; Protein Kinases, catalytic domain