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    Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 399510, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Map4k5provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 5provided by MGI
    Primary source
    MGI:MGI:1925503
    See related
    Ensembl:ENSMUSG00000034761 AllianceGenome:MGI:1925503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KHS; GCKR; MAPKKKK5; 4432415E19Rik
    Summary
    Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Is expressed in metanephros and testis. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.4), bladder adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C2; 12 28.94 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69850531..69939937, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69803757..69893163, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2387 Neighboring gene STARR-positive B cell enhancer mm9_chr12:70834549-70834850 Neighboring gene distal membrane arm assembly component 2 like Neighboring gene VISTA enhancer mm122 Neighboring gene cyclin dependent kinase like 1 Neighboring gene microRNA 681 Neighboring gene RIKEN cDNA 4930512B01 gene Neighboring gene STARR-seq mESC enhancer starr_32378 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 4931403G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E8487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70968432-70968671 Neighboring gene STARR-seq mESC enhancer starr_32379 Neighboring gene atlastin GTPase 1 Neighboring gene STARR-seq mESC enhancer starr_32381 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene predicted gene, 52003 Neighboring gene salvador family WW domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Shi CS, et al. Mol Cell Biol, 2006 Sep. PMID 16914735, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Germinal center kinase-related enzyme (GCKR) facilitates both canonical and noncanonical Wnt signaling in B lymphocytes.
      Title: The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 5
    Names
    MAPK/ERK kinase kinase kinase 5
    MEK kinase kinase 5
    MEKKK 5
    NP_958927.2
    XP_006516117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201519.2 → NP_958927.2  mitogen-activated protein kinase kinase kinase kinase 5

      See identical proteins and their annotated locations for NP_958927.2

      Status: VALIDATED

      Source sequence(s)
      AK019468, AK032123, AK053775, AK084891, BC048173
      UniProtKB/Swiss-Prot
      Q6PEQ2, Q8BPM2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73
      UniProtKB/TrEMBL
      E9PX30
      Conserved Domains (3) summary
      smart00036
      Location:512 → 827
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:20 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69850531..69939937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516054.4 → XP_006516117.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

      See identical proteins and their annotated locations for XP_006516117.1

      UniProtKB/TrEMBL
      E9PX30
      Related
      ENSMUSP00000106199.2, ENSMUST00000110570.8
      Conserved Domains (2) summary
      smart00036
      Location:512 → 826
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06646
      Location:10 → 277
      STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPM2.2 GenPept UniProtKB/Swiss-Prot:Q8BPM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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